ABSTRACT
We compared the efficacy of misoprostol with that of prostaglandin E2 in cervical ripening and labour induction. Thus 238 women with rupture of membranes beyond 36 weeks gestation without labour were randomized to receive 50 microg misoprostol vaginal gel or 5 mg of prostaglandin E2 gel. Bishop score was evaluated before drug application and 6 hours later. Clinical data and perinatal outcome were recorded. Mean time from induction to delivery and the need for oxytocin were significantly less in the misoprostol group. There were no significant differences in spontaneous labour rate, type of delivery and perinatal outcome. It is concluded that intravaginal misoprostol is safe and more effective than prostaglandin E2 for preinduction cervical ripening in premature rupture of membranes beyond 36 weeks gestation.
Subject(s)
Fetal Membranes, Premature Rupture/drug therapy , Labor, Induced/methods , Misoprostol/administration & dosage , Oxytocics/administration & dosage , Administration, Intravaginal , Cervical Ripening/drug effects , Delivery, Obstetric/methods , Delivery, Obstetric/statistics & numerical data , Dinoprostone/administration & dosage , Dinoprostone/adverse effects , Dinoprostone/pharmacology , Female , Fetal Distress/chemically induced , Fetal Distress/diagnosis , Gels , Humans , Labor, Induced/adverse effects , Misoprostol/adverse effects , Misoprostol/pharmacology , Oxytocics/adverse effects , Oxytocics/pharmacology , Patient Selection , Pregnancy , Pregnancy Outcome/epidemiology , Pregnancy Trimester, Third , Safety , Tachycardia/chemically induced , Tachycardia/diagnosis , Time Factors , Treatment Outcome , Vaginal Creams, Foams, and JelliesABSTRACT
We compared the efficacy of misoprostol with that of prostaglandin E2 in cervical ripening and labour induction. Thus 238 women with rupture of membranes beyond 36 weeks gestation without labour were randomized to receive 50 microg misoprostol vaginal gel or 5 mg of prostaglandin E2 gel. Bishop score was evaluated before drug application and 6 hours later. Clinical data and perinatal outcome were recorded. Mean time from induction to delivery and the need for oxytocin were significantly less in the misoprostol group. There were no significant differences in spontaneous labour rate, type of delivery and perinatal outcome. It is concluded that intravaginal misoprostol is safe and more effective than prostaglandin E2 for preinduction cervical ripening in premature rupture of membranes beyond 36 weeks gestation
