Ultrasound assisted phytochemical extraction of persimmon fruit peel: Integrating ANN modeling and genetic algorithm optimization.

In the present study, ultrasound assisted extraction (UAE) of phytochemicals from persimmon fruit peel (PFP) was modeled using an artificial neural network (ANN) and optimized by integrating with genetic algorithm (GA). The range of process parameters selected for conducting the experiments was ultrasonication power (XU) 150---350 W, extraction temperatures (XT) 30---70 °C, solid to solvent ratio (XS) 1:15---1:35 g/ml, and ethanol concentration (XC) 40---80 %. The range of responses total phenolic content (YP), antioxidant activity (YA), total beta carotenoid (YB) and total flavonoid content (YF) at various independent variables combinations were found to be 7.72---24.62 mg GAE/g d.w., 51.44---85.58 %DPPH inhibition, 24.78---56.56 µg/g d.w. and 0.29---1.97 mg QE/g d.w. respectively. The modelling utilised an ANN architecture with a configuration of 4-12-4. The training process employed the Levenberg-Marquardt method, whereas the activation function chosen for the layers was the log sigmoid. The optimum condition predicted by the hybrid ANN-GA model for the independent variables, XU, XT, XS and XC was found to be 230.18 W, 50.66 °C, 28.27 g/ml, and 62.75 % respectively. The extraction process was carried out for 25 min, with 5-minute intervals, at various temperatures between 30 and 60 °C, to investigate the kinetic and thermodynamic characteristics of the process, under the optimal conditions of XU, XS and XC. The UAE of phytochemicals from persimmon peel followed pseudo second order kinetic model and the extraction process was endothermic in nature.

Phytochemical Properties, Extraction, and Pharmacological Benefits of Naringin: A Review.

This review describes the various innovative approaches implemented for naringin extraction as well as the recent developments in the field. Naringin was assessed in terms of its structure, chemical composition, and potential food sources. How naringin works pharmacologically was discussed, including its potential as an anti-diabetic, anti-inflammatory, and hepatoprotective substance. Citrus flavonoids are crucial herbal additives that have a huge spectrum of organic activities. Naringin is a nutritional flavanone glycoside that has been shown to be effective in the treatment of a few chronic disorders associated with ageing. Citrus fruits contain a common flavone glycoside that has specific pharmacological and biological properties. Naringin, a flavone glycoside with a range of intriguing characteristics, is abundant in citrus fruits. Naringin has been shown to have a variety of biological, medicinal, and pharmacological effects. Naringin is hydrolyzed into rhamnose and prunin by the naringinase, which also possesses l-rhamnosidase activity. D-glucosidase subsequently catalyzes the hydrolysis of prunin into glucose and naringenin. Naringin is known for having anti-inflammatory, antioxidant, and tumor-fighting effects. Numerous test animals and cell lines have been used to correlate naringin exposure to asthma, hyperlipidemia, diabetes, cancer, hyperthyroidism, and osteoporosis. This study focused on the many documented actions of naringin in in-vitro and in-vivo experimental and preclinical investigations, as well as its prospective therapeutic advantages, utilizing the information that is presently accessible in the literature. In addition to its pharmacokinetic characteristics, naringin's structure, distribution, different extraction methods, and potential use in the cosmetic, food, pharmaceutical, and animal feed sectors were discussed.