ABSTRACT
Duodenal nodularity is an uncommon endoscopic finding charac-trized by numerous visible mucosal nodules in the duodenum. It is important to consider giardiasis in patients with symptoms include abdominal pain, nausea, anorexia, diarrhea, vomiting, weight loss and abdominal distension. It is also important to remind giardiasis in patients with duodenal nodularity.
Subject(s)
Duodenitis/diagnostic imaging , Duodenitis/parasitology , Giardiasis/complications , Adult , Duodenitis/pathology , Dyspepsia/parasitology , Endoscopy, Gastrointestinal , Female , Giardiasis/diagnostic imaging , Giardiasis/pathology , Humans , Weight LossABSTRACT
OBJECTIVE: The regeneration process causes the liver to achieve an adequate volume and function after major hepatectomy or living donor liver transplantation. Sildenafil, a selective phosphodiesterase-5 inhibitor used for erectile dysfunction, impacts the liver by enhancing the effects of nitric oxide. The aim of this study was to investigate the influence of sildenafil on liver regeneration in rats after partial hepatectomy. METHODS: Sixty young female Wistar Albino rats were randomly divided into three equal groups before 70% hepatectomy. Thereafter, we administered intraperitoneal saline to the control group (G1); 10 µg/kg sildenafil to the low-dose group (G2) and 100 µg/kg to the high-dose sildenafil group (G3). Half of the rats per group were sacrificed on the first and the other half on the fifth postoperative day after partial hepatectomy. Regeneration was assessed using three methods: (1) the formula described by Kwon et al formula, (2) the average number of mitotic figures in 10 microscopic fields, and (3) the average of Ki-67-positive nuclei in 1000 cells using immunohistochemistry. RESULTS: Although, the hepatic regeneration and mitosis rates were similar in all three groups, Ki-67 levels were significantly higher in both G2 and G3 than the control group on the first postoperative day. Hepatic regeneration was significantly greater in G2 and G3 than the control group as was the mitosis rate in the G2 group versus the two groups. By the 5th postoperative day Ki-67 levels were similar in the three groups. CONCLUSION: Sildenafil treatment accelerated hepatic regeneration after partial hepatectomy in rats.
Subject(s)
Hepatectomy , Liver Regeneration/drug effects , Liver/drug effects , Liver/surgery , Phosphodiesterase 5 Inhibitors/pharmacology , Piperazines/pharmacology , Sulfones/pharmacology , Animals , Cell Proliferation/drug effects , Female , Immunohistochemistry , Ki-67 Antigen/metabolism , Liver/pathology , Mitosis/drug effects , Models, Animal , Purines/pharmacology , Rats , Rats, Wistar , Sildenafil Citrate , Time FactorsSubject(s)
Anastomosis, Surgical/methods , Jejunum/transplantation , Short Bowel Syndrome/surgery , Transplantation, Isogeneic/physiology , Wound Healing/physiology , Animals , Graft Survival/physiology , Intestinal Obstruction/epidemiology , Jejunum/surgery , Postoperative Complications/epidemiology , Rats , Rats, Wistar , Time Factors , Transplantation, Isogeneic/mortality , Transplantation, Isogeneic/pathologyABSTRACT
Mesenteric panniculitis is a non-neoplastic inflammatory process affecting the adipose tissue of the mesentery. It is an extremely rare disease. We report the case of a 30-year-old man with mesenteric panniculitis and describe the radiologic findings.
