ABSTRACT
The aim of this patient and public involvement and engagement (PPIE) work was to explore improvised theatre as a tool for facilitating bi-directional dialogue between researchers and patients/members of the public on the topic of polygenic risk scores (PRS) use within primary or secondary care. PRS are a tool to quantify genetic risk for a heritable disease or trait and may be used to predict future health outcomes. In the United Kingdom (UK), they are often cited as a next-in-line public health tool to be implemented, and their use in consumer genetic testing as well as patient-facing settings is increasing. Despite their potential clinical utility, broader themes about how they might influence an individual's perception of disease risk and decision-making are an active area of research; however, this has mostly been in the setting of return of results to patients. We worked with a youth theatre group and patients involved in a PPIE group to develop two short plays about public perceptions of genetic risk information that could be captured by PRS. These plays were shared in a workshop with patients/members of the public to facilitate discussions about PRS and their perceived benefits, concerns and emotional reactions. Discussions with both performers and patients/public raised three key questions: (1) can the data be trusted?; (2) does knowing genetic risk actually help the patient?; and (3) what makes a life worthwhile? Creating and watching fictional narratives helped all participants explore the potential use of PRS in a clinical setting, informing future research considerations and improving communication between the researchers and lay members of the PPIE group.
ABSTRACT
Suicide is one of the leading causes of death among young people aged 15 to 29 years of age. Ideation or suicidal thoughts , which precedes suicide is sometimes normalized and excused thereby missing avertable deaths within a given context. Understanding suicide ideation and the associated social correlates within contexts can provide cues on how to mitigate suicide. This paper examines the potential social factors that are shaping suicidal ideation among young people in two universities in Nigeria. Based on a mixed-method design, a survey was conducted among a proportionate sample of 500 young people (18-25years that are undergraduates). Four Focus Group Discussion sessions were also held among the same group and six semi-structured interviews with social workers at both universities. Quantitative evidence associated irregular financial support (OR = 0.60; p < 0.05) and broken intimate relationship (OR = 1.57; P < 0.05) with suicide ideation. Findings from the qualitative component also considered undergraduates that have academic challenges, engage in substance abuse, and have parents with marital problems to be prone to suicidal ideation. Suicidal ideation among these young people is embedded in their network of relationships, which can be mitigated when the quality of support systems is responsive and adequately accessed.
