When liquids and fricatives outrank stops: A Kuwaiti Arabic-speaking child with Down syndrome and protracted phonological development.

This paper describes the phonological system of a monolingual Kuwaiti Arabic-speaking 9-year-old girl with Down Syndrome (DS) as part of a special crosslinguistic issue presenting individual profiles of children with protracted phonological development within the framework of constraints-based nonlinear phonology. Her responses to a 100-word speech test were audio-recorded and transcribed narrowly by two native speakers. Analyses showed low accuracy for word shapes (CV sequences), primarily because of expected deletion patterns in initial weak syllables and clusters, but also reflecting inaccuracies in segment length. Vowel match was also relatively low. For consonants, she unexpectedly showed lower accuracy for stops than typically later-developing liquids and fricatives. This case study provides researchers and speech-language pathologists with broader information about expected and unexpected patterns in children with DS and protracted phonological development in general.

Formulation and characterization of tobramycin-chitosan nanoparticles coated with zinc oxide nanoparticles.

Herein we describe the preparation, characterization and the antibacterial effect of Tobramycin-chitosan nanoparticles (TOB-CS NPs) coated with zinc oxide nanoparticles (ZnO NPs). Four formulations of TOB-CS NPs (A-D) were prepared to study the effect of experimental variables on the NPs behavior. Two formulations of ZnO NPs were prepared using the solvothermal and the precipitation methods (ZnO1 and ZnO2), and then characterized. TOB-CS NPs (Formula d) was coated with the ZnO1. Moreover, the antibacterial activity of TOB-CS NPs, ZnO NPs and the coated nanoparticles against S. aureus and E. coli was examined. Changing the variables in preparing TOB-CS NPs resulting in variabilities in sizes (297.6-1116.3 nm), charges (+8.29-+39.00 mV), entrapment (51.95-90.60%). Further, TOB release was sustained over four days. ZnO NPs have sizes of 47.44 and 394.4 nm and charges of -62.3 and 89.4 mV when prepared by solvothermal and precipitation technique, respectively. Coated TOB-CS NPs had a size of 342 nm, a charge of +4.39 and released 100 µg/ mL of the drug after four days. The antimicrobial activity of TOB-CS NPs was lower than free TOB against S. aureus and E. coli. The coated NPs showed higher antimicrobial effect in comparison to formula D and ZnO1. In conclusion, coating TOB-CS NPs with ZnO NPs exhibited a great antibacterial effect that may be sustained for days.

Phonological development in school-aged Kuwaiti Arabic children with Down syndrome: A pilot study.

BACKGROUND: Studies on atypical phonological development are very limited for Arabic, and to date no studies on Arabic have investigated the development of phonology in children with conditions such as Down Syndrome. Arabic, like other Semitic languages, is rich in consonants and consonantal variation. However, it differs greatly from region to region, and so reports on individual dialects or regional dialects are necessary. Kuwaiti Arabic, the focus of the present paper, is similar to other dialects in the Gulf region. AIM: This is a preliminary study to examine the phonological development of school-aged Kuwaiti Arabic-speaking children with Down Syndrome in order to start to address the research gap noted above. METHODS & PROCEDURES: Six Kuwaiti Arabic-speaking children were recruited for this pilot study from integrated public schools where children with disabilities and typically developing children are enrolled in the State of Kuwait: three male and three female students, age range of 5;10-12;3 years. All participants had the same single word speech test of 100 words. The first author, a native speaker of Kuwaiti Arabic, audio-recorded and phonetically transcribed the sample with the help of two speech-language pathologists from Kuwait. Reliability was confirmed by the first author and another expert rater. Both match and mismatch analyses were performed and compared to existing literature. OUTCOMES & RESULTS: Overall consonant accuracy across participants was 50%, with a variety of matches across consonant categories. However, the participants also exhibited a wide range of mismatches across positions in words and phonological features (place, manner, and laryngeal features). Place substitutions were the most frequent. Some sounds exhibited double (place and manner) mismatches. The most common word structure mismatch was consonant cluster reduction (no matches for word-initial clusters). Mismatch patterns resembled both those of normally developing Kuwaiti children and those of English speakers with Down Syndrome in certain ways. CONCLUSIONS & IMPLICATIONS: This pilot study provides preliminary information for clinicians regarding the speech or children with Down Syndrome (DS), not only in Kuwait but also in the Gulf region where there are similarities to Kuwaiti Arabic.

Kuwaiti Arabic: acquisition of singleton consonants.

BACKGROUND: Arabic, a Semitic language of the Afro-Asiatic variety, has a rich consonant inventory. Previous studies on Arabic phonological acquisition have focused primarily on dialects in Jordan and Egypt. Because Arabic varies considerably across regions, information is also needed for other dialects. AIMS: To determine acquisition benchmarks for singleton consonants for Kuwaiti Arabic-speaking 4-year-olds. METHODS & PROCEDURES: Participants were 80 monolingual Kuwaiti Arabic-speaking children divided into two age groups: 46-54 and 55-62 months. Post-hoc, eight children were identified as possibly at risk for protracted phonological development. A native Kuwaiti Arabic speaker audio-recorded and transcribed single-word speech samples (88 words) that tested consonants across word positions within a variety of word lengths and structures. Transcription reliability (point-to-point) was 95% amongst the authors, and 87% with an external consultant. Three acquisition levels were designated that indicated the proportion of children with no mismatches ('errors') for a given consonant: 90%+ of children, 75-89%, fewer than 75%. Mismatch patterns were described in terms of a phonological feature framework previously described in the literature. OUTCOMES & RESULTS: The Kuwaiti 4-year-olds produced many singleton consonants accurately, including pharyngeals and uvulars. Although the older age group had fewer manner and laryngeal mismatches than the younger age group, consonants still developing at age 5 included coronal fricatives and affricates, trilled /r/ and some uvularized consonants ('emphatics'). The possible at-risk group showed mastery of fewer consonants than the other children. By feature category, place mismatches were the most common, primarily de-emphasis and lack of contrast for [coronal, grooved] (distinguishing alveolar from interdental fricatives). Manner mismatches were next most common: the most frequent substitutions were [+lateral] [l] or other rhotics for /r/, and stops for fricatives. Laryngeal mismatches were few, and involved partial or full devoicing. Group differences generally reflected proportions of mismatches rather than types. CONCLUSIONS & IMPLICATIONS: Compared with studies for Jordanian and Egyptian Arabic, Kuwaiti 4-year-olds showed a somewhat more advanced consonant inventory than same age peers, especially with respect to uvulars, pharyngeals and uvularized (emphatic) consonants. Similar to the other studies, consonant categories yet to master were: [+trilled] /r/, coronal fricative feature [grooved], [+voiced] fricatives /ʕ, z/ and the affricate /d͡͡ʒ/ and some emphatics. Common mismatch patterns generally accorded with previous studies. This study provides criterion reference benchmarks for Kuwaiti Arabic consonant singleton acquisition in 4-year-olds.

Phonological development of Kuwaiti Arabic: preliminary data.

An overview of Kuwaiti Arabic is presented, with very preliminary data from two typically developing brothers (ages 2;4 and 5;2) and a 6-year-old with a severe sensorineural hearing impairment. The siblings show early mastery of many aspects of the complex Arabic phonological system, with universally expected later mastery of coronal fricatives and /r/. The 6-year-old shows patterns typical of children with hearing impairments, e.g. hypernasality, a prevalence of 'visible' segments, particularly labials, and simplified syllable structure. Her accurate use of /l/, /r/, and some gutturals, however, raise questions about the enhanced perceptibility and functionality of these segments in Arabic.