ABSTRACT
The utilization of herbal formulations for the management of reproductive tract disorders has been a longstanding practice in traditional medicine. In this study, we investigated the efficacy of a herbal extract, Shalmali (Bombax ceiba), in addressing uterine bleeding, a common concern in gynecological health. Through gene expression analysis, this study examined the impact of Shalmali extract on key genes associated with uterine bleeding, namely ESR1, CD56, and SDF-1, in the human endometrial stromal cell line (T HESC). Our findings revealed a dose-dependent decrease in ESR1 and CD56 gene expression levels following treatment with Shalmali extract, suggesting its potential to modulate hormonal and cellular processes involved in uterine bleeding. Notably, an increase in SDF-1 gene expression was observed, indicating a possible role of Shalmali extract in promoting tissue repair and regeneration. Comparison with the standard drug tranexamic acid demonstrated similar effects on gene expression levels, further validating the therapeutic potential of Shalmali extract. Agarose gel electrophoresis images supported these findings, showing reduced gene expression in cells treated with Shalmali extract comparable to those treated with tranexamic acid. These results underscore the promising efficacy of Shalmali extract as a natural alternative for managing uterine bleeding, potentially offering a safe and effective treatment option for individuals seeking traditional remedies for gynecological concerns. Further research is warranted to elucidate the underlying mechanisms of action and assess the long-term safety and efficacy of Shalmali extract in clinical settings.
ABSTRACT
The aim of presenting this case is to highlight the fact that extranodal manifestation of Rosai Dorfman Disease (RDD) without lymphadenopathy was seen in a teenaged girl with recurrent episodes of epistaxis, due to a lobulated mass in the nasopharynx, which mimicked malignancy. This case is a rare presentation because the extranodal manifestation of RDD in multisystem organs are reported in literature, but the nasopharyngeal manifestation without lymphadenopathy is unique. The clinical presentation and surgical management of the case by endoscopic sinus surgery, the aetiopathology, differential diagnosis and review of literature are described here.
ABSTRACT
Pseudocyst of the pinna, a benign idiopathic cystic swelling is an uncommon condition. In the medline search there are over 113 cases reported in literature. Engel in 1966 reported the incidence in Chinese community. In this review article we describe the etiopathogenesis, demographic statistics and treatment modalities.This is a retrospective study of six cases treated by the senior author in the dept of Otorhinolaryngology, Head & Neck Surgery, Apollo Hospital Chennai, South India between 1993 through 2003. There is preponderance of incidence in adult male (5 cases) and a single case in a female. The author highlights the modalities of treatment and opines that the surgical technique described by Lim et al, with little modification is the gold standard, which retains the architecture of the pinna. Conservative methods adopted by others have failed.
ABSTRACT
Trans Nasal Esophagoscopy (TME) - a new concept to visualize the esophagus in office practice has obviated the conventional rigid esophagoscope, which is a cumbersome, time consuming procedure and sometimes associated with complications like perforation. Many surgeons in the West using flexible endoscope after air insufflation have tried this procedure. We fabricated a new gadget far the purpose of air insufflation in collaboration with the department of biomedical engineering, Apollo hospitals, Chennai which substitute oxygen insufflation through central supply or through the flow meter connected to an O(2) cylinder. In this article we have discussed various uses of the procedure in diagnosis A therapeutic application in an E.N.T office practice and also the unique technique of air insufflation with the new gadget.
