ABSTRACT
Experimental investigations on the spectrum and degree of the expression of trental antiviral activity were carried out. The investigations were done in cell cultures and laboratory animals using laboratory strains (including drug-resistant ones) of 13 viruses, causative agents of human and animal infections. The drug demonstrated its activity against 8 viruses of 7 families. It was highly active against 5 viruses: herpes simplex virus (including its acyclovir-resistant strain), vaccinia virus (including its methisazone-resistant strain), rotavirus and tick-borne encephalitis virus. As regards other viruses, its activity was less pronounced (hepatitis JA virus) or low (vesicular stomatitis virus, West Nile virus). It was concluded that, being a cardiovascular drug, trental was an effective broad spectrum virus inhibitor.
Subject(s)
Antiviral Agents/pharmacology , Pentoxifylline/pharmacology , Animals , Antiviral Agents/therapeutic use , Depression, Chemical , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug Resistance, Microbial , Mice , Microbial Sensitivity Tests , Pentoxifylline/therapeutic use , Rabbits , Virus Diseases/drug therapy , Viruses/drug effectsABSTRACT
The activity of 24 antibiotics was studied in treatment of albino mice with experimental encephalitis caused by West Nile virus. The antiviral activity of gentamicin and kanamycin was stated. The survival rate of the animals 19. contaminated with 10-100 LD50 of the West Nile virus and treated parenterally with gentamicin in a dose of 80 to 400 micrograms/mouse was higher than that in the controls by 29.5 to 100 per cent and depended on the drug regimen. The efficacy of kanamycin was lower. The chemotherapeutic indices of gentamicin and kanamycin amounted to 100 and 10, respectively. Since there are no schemes for chemotherapy of the infection caused by the West Nile virus and the respective vaccines are not available the use of the antibiotics and gentamicin in particular appears to be promising in the disease prevention and treatment.
Subject(s)
Disease Models, Animal , Gentamicins/therapeutic use , Kanamycin/therapeutic use , West Nile Fever/drug therapy , West Nile virus/drug effects , Animals , Antiviral Agents , Drug Evaluation, Preclinical , Gentamicins/pharmacology , Kanamycin/pharmacology , Mice , West Nile Fever/microbiologySubject(s)
Antiviral Agents , Lincomycin/therapeutic use , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Encephalitis Viruses/drug effects , Encephalitis Viruses/physiology , Encephalitis, Arbovirus/drug therapy , Encephalitis, Arbovirus/mortality , Encephalomyelitis/drug therapy , Encephalomyelitis/mortality , Mice , Vero Cells , Virus Replication/drug effectsABSTRACT
A method for tick-borne encephalitis virus reproduction was developed in female Ixodes ticks in the period of postlarval development, if they were kept at elevated temperature (23-37 degrees C). It ensures further conservation of the agent in carriers by decreasing tick maintenance temperature to 4 degrees C.
