ABSTRACT
In this paper a new method based on artificial neural networks (ANN), is introduced for identifying pathogenic antibodies in Systemic Lupus Erythmatosus (SLE). dsDNA binding antibodies have been implicated in the pathogenesis of this autoimmune disease. In order to identify these dsDNA binding antibodies, the protein sequences of 42 dsDNA binding and 608 non-dsDNA binding antibodies were extracted from Kabat database and encoded using a physicochemical property of their amino acids namely Hydrophilicity. Encoded antibodies were used as the training patterns of a general regression neural network (GRNN). Simulation results show that the accuracy of proposed method in recognizing dsDNA binding antibodies is 83.2%. We have also investigated the roles of the light and heavy chains of anti-dsDNA antibodies in binding to DNA. Simulation results concur with the published experimental findings that in binding to DNA, the heavy chain of anti-dsDNA is more important than their light chain.
ABSTRACT
In this paper a novel approach for cardiac arrhythmias detection is proposed. The proposed method is based on using independent component analysis (ICA) and wavelet transform to extract important features. Using the extracted features different machine learning classification schemas, MLP and RBF neural networks and K-nearest neighbor, are used to classify 274 instance signals from the MIT-BIH database. Simulations show that multilayer neural networks with Levenberg-Marquardt (LM) back propagation algorithm provide the optimal learning system. We were able to obtain 98.5% accuracy, which is an improvement in comparison with the similar works.
