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Biomol NMR Assign ; 15(2): 341-345, 2021 10.
Article in English | MEDLINE | ID: mdl-33914244

ABSTRACT

During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS).


Subject(s)
Middle East Respiratory Syndrome Coronavirus , Nuclear Magnetic Resonance, Biomolecular , Nucleocapsid Proteins/chemistry , Models, Molecular , Protein Domains
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