A Nonlinear Rate Microsensor utilising Internal Resonance.

Micro- and nano-resonators have been studied extensively both for the scientific viewpoint to understand basic interactions at small scales as well as for applied research to build sensors and mechanical signal processors. Majority of the resonant microsystems, particularly those manufactured at a large scale, have employed simple mechanical structures with one dominant resonant mode, such as in timing resonators, or linearly coupled resonant modes, as in vibratory gyroscopes. There is an increasing interest in the development of models and methods to better understand the nonlinear interactions at micro- and nano-scales and also to potentially improve the performance of the existing devices in the market beyond limits permissible by the linear effects. Internal resonance is a phenomenon that allows for nonlinear coupling and energy transfer between different vibration modes of a properly designed system. Herein, for the first time, we describe and experimentally demonstrate the potential for employing internal resonance for detection of angular rate signals, where the Coriolis effect modifies the energy coupling between the distinct drive and sense vibration modes. In doing so, in addition to providing a robust method of exciting the desired mode, the proposed approach further alleviates the mode-matching requirements and reduces instabilities due to the cross-coupling between the modes in current linear vibratory gyroscopes.

Monitoring the spreading stage of lung cells by silicon nanowire electrical cell impedance sensor for cancer detection purposes.

We developed a silicon nanowire based electrical cell impedance sensor (SiNW-ECIS) as an instrument that detects cancerous cultured living lung cells by monitoring their spreading state at which the cells stretched and become extended on nanowires. Further current penetration into the extended membrane of malignant cells in respect to normal ones (In the first 6h after cells interaction with surface) are the key mechanism in our diagnosis procedure. The developed device applied to monitor the spreading-induced electrical differences between cancerous and normal lung cells in an integral fashion. Detection was performed so faster than the time required to complete cells mitosis. Morphology and architecture of doped Si nanowires covered microelectrodes observably enhance the contact area between cells and electrodes which support accurate signal recording from stretched cells as indicated by SEM and florescent images.

A single-cell correlative nanoelectromechanosensing approach to detect cancerous transformation: monitoring the function of F-actin microfilaments in the modulation of the ion channel activity.

Cancerous transformation may be dependent on correlation between electrical disruptions in the cell membrane and mechanical disruptions of cytoskeleton structures. Silicon nanotube (SiNT)-based electrical probes, as ultra-accurate signal recorders with subcellular resolution, may create many opportunities for fundamental biological research and biomedical applications. Here, we used this technology to electrically monitor cellular mechanosensing. The SiNT probe was combined with an electrically activated glass micropipette aspiration system to achieve a new cancer diagnostic technique that is based on real-time correlation between mechanical and electrical behaviour of single cells. Our studies demonstrated marked changes in the electrical response following increases in the mechanical aspiration force in healthy cells. In contrast, such responses were extremely weak for malignant cells. Confocal microscopy results showed the impact of actin microfilament remodelling on the reduction of the electrical response for aspirated cancer cells due to the significant role of actin in modulating the ion channel activity in the cell membrane.