ABSTRACT
AIM: To evaluate the efficiency of using the vitamin and mineral complex (VMC) ALFAVIT Diabetes in the combination therapy of diabetic polyneuropathy (DPNP) in adolescents. SUBJECTS AND METHODS: A study group comprised 30 children with diabetic peripheral polyneuropathy, whose combination therapy included ALFAVIT Diabetes as one tablet t.i.d. for 2 months. A comparison group consisted of 20 adolescents with DPNP who did not take the complex. Before and 2 months after the study, the children's state was assessed from the data of a physical examination with mandatory blood pressure and pulse measurements and a neurological study, from carbohydrate (basal glycemia, glycemic variability, glycated hemoglobin) and lipid (total cholesterol and its fractions) metabolic parameters, and from the findings of electromyography (EMG). RESULTS: Incorporation of the VMC ALFAVIT Diabetes into the combination therapy contributed to the ameliorated clinical manifestations of DPNP. There were positive electrophysiological changes, as evidenced by EMG. The VMC ALFAVIT Diabetes showed good tolerability and caused no adverse reactions. CONCLUSION: The performed trials have indicated that it is expedient to use the VMC ALFAVIT Diabetes in adolescents with type 1 diabetes mellitus and DPNP.
Subject(s)
Diabetes Mellitus, Type 1/complications , Diabetic Neuropathies , Insulin/therapeutic use , Neurologic Examination/methods , Trace Elements/administration & dosage , Vitamins/administration & dosage , Adolescent , Blood Glucose/analysis , Blood Glucose Self-Monitoring/methods , Complementary Therapies/methods , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/drug therapy , Diabetic Neuropathies/diagnosis , Diabetic Neuropathies/drug therapy , Diabetic Neuropathies/etiology , Diabetic Neuropathies/metabolism , Dietary Supplements , Drug Combinations , Drug Therapy, Combination , Electromyography/methods , Female , Glycated Hemoglobin/analysis , Humans , Hypoglycemic Agents/therapeutic use , Male , Neuroprotective Agents/administration & dosage , Treatment OutcomeABSTRACT
The use of an Amfit-0,2/10-01 apparatus generating low-intensity ultrahigh frequency (UHF) electromagnetic radiation improved efficiency of therapy of sick children. This treatment allowed to reduce the frequency of intake of anesthetics in the post-operative period, correct metabolic disorders in children with type 1 diabetes mellitus, reduce severity of diabetic nephropathy and polyneuropathy, prevent formation of fresh foci of lipoid necrobiosis. The results of the study indicate that the use of low-intensity UHF electromagnetic radiation may be recommended for more extensive introduction into practical clinical work of pediatric endocrinologists and surgeons.
Subject(s)
Microwaves/therapeutic use , Pediatrics/methods , Analgesia/methods , Child , Combined Modality Therapy , Diabetes Complications/therapy , HumansABSTRACT
The level of plasma fibronectin was determined in healthy newborns (45 plasma samples were examined in the control group) and in newborns with pyo-septic diseases (67 plasma samples were examined) by the immunoenzyme method (on the basis of the "sandwich" modification of the immunoenzyme analysis). Noticeable hypofibrinectinemia was observed in the infants with pyo-inflammatory diseases, particularly in cases of generalized forms. Combined modality etiopathogenetic therapy including i.v. plasma transfusion, did not exceed fibronectin deficiency in clinical convalescence of infants. Fibronectin deficiency is regarded as a risk factor of the development and generalization of pyo-inflammatory diseases.
