ABSTRACT
Experiments on dogs with acute coronary insufficiency were made to show that nonachlazine in doses of 3 and 5 mg/kg considerably reduces or even prevents the rise of S-T segment on the epicardial electrogram depending on the intensity of ischemia. Hydroxyfedrine in doses of 0.1 and 0.3 mg/kg deteriorates the electrogram. Nonachlazine prevents an increase in the content of lactate and in the lactate/pyruvate ratio in the blood outflowing from the focus of ischemia. On the contrary, hydroxyfedrine raises the characteristics in question. Nonachlazine improves blood supply of the ischemized myocardium, increases the retrograde coronary blood flow and redistributes blood in favour of the affected myocardial area. Hydroxyfedrine lowers the retrograde blood supply of the area of ischemia and redistributes blood in favour of the unaffected areas of the heart.
Subject(s)
Adrenergic beta-Agonists/therapeutic use , Coronary Disease/drug therapy , Nonachlazine/therapeutic use , Oxyfedrine/therapeutic use , Phenothiazines/therapeutic use , Propiophenones/therapeutic use , Acute Disease , Animals , Coronary Circulation/drug effects , Coronary Disease/physiopathology , Dogs , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , ElectrocardiographyABSTRACT
It has been shown that nonachlazin in a dose of 6 mg/kg injected intravenously to cats 15 minutes after occlusion of the left descending coronary artery produced a 42% decrease in the content of lactic acid in the left heart ventricle as compared to its content in ischemic myocardium. Nonachlazin brought to normal the content of ATP that had been decreased under acute myocardial ischemia. Concurrent recording of ECG readings showed them to be improved. The parameters studied did not change in the animals with intact myocardium after the drug administration. It is suggested that the favourable clinical effect seen is accounted for by nonachlazin-activated glycolysis and oxidative mitochondrial phosphorylation in the myocardium.
