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Acta Otorhinolaryngol Ital ; 42(3): 250-256, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35880366

ABSTRACT

Objectives: To determine the serum levels of interleukin-1beta (IL-1ß) in patients with acquired laryngotracheal stenosis (ALTS) and healthy volunteers and compare levels between serum and tissue of the stenotic segment. Materials and methods: An exploratory cohort study included 20 participants with ALTS and 5 healthy volunteers. ALTS group was categorised into mild and severe according to grade of stenosis and presence of tracheostomy. Comparisons of serum levels of IL-1ß between pre- and post-surgical intervention and between blood and tissue samples in the severe ALTS group were made. Correlation of IL-1ß levels between blood and tissue was assessed using Spearman's correlation. Results: Severe ALTS patients showed higher serum levels of IL-1ß compared to mild ALTS and healthy volunteers (p = 0.045). IL-1ß was higher before surgical intervention than after surgical intervention (p = 0.003). There was a strong positive correlation of IL-1ß between serum and tissue (r = 0.74, p = 0.035). Conclusion: Serum levels of IL-1ß are higher in ALTS patients than in healthy controls and positively correlate with tissue levels. The decreasing trend of serum IL-1ß observed following successful surgical intervention reflects the absence of ongoing inflammation at the stenotic segment.


Subject(s)
Interleukin-1beta/blood , Laryngostenosis , Tracheal Stenosis , Cohort Studies , Constriction, Pathologic , Humans , Laryngostenosis/etiology , Laryngostenosis/surgery , Tracheal Stenosis/etiology , Tracheal Stenosis/surgery
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