ABSTRACT
The above study was undertaken in order to demonstrate the efficacy of ketanserin in mild to moderate essential arterial hypertension. Twenty-two patients, mean age 49.7 yrs., were studied during 36 months. After a 15-day washout period with clinical and instrumental assessment of basal conditions, treatment with 40 mg ketanserin every 12 hrs. was started. Pressure, blood chemistry and instrumental investigation were carried out systematically and showed the hypotensive action of ketanserin as well as a significant (about 12%) rise in HDL-cholesterol.
Subject(s)
Hypertension/drug therapy , Ketanserin/therapeutic use , Adult , Blood Pressure/drug effects , Cholesterol, HDL/blood , Cholesterol, HDL/drug effects , Drug Evaluation , Female , Humans , Ketanserin/administration & dosage , Male , Middle AgedABSTRACT
An immunological evaluation was performed before therapy and every four months during the first year of treatment with auranofin in 6 children with juvenile chronic arthritis. The immunological tests included: IgG, IgA, IgM, IgE and "natural" antibody serum levels, CH50 of the classical and alternative complement pathways, PWM-induced IgM production in vitro, and polymorphonuclear neutrophil functions. A reduction of the in vitro IgM synthesis and in the CH50 of the classical pathway of complement, and a normalization of impaired chemotaxis, occurred in patients who presented a clinically significant improvement during auranofin treatment.
Subject(s)
Arthritis, Juvenile/drug therapy , Aurothioglucose/analogs & derivatives , Gold/analogs & derivatives , Antibody Formation/drug effects , Arthritis, Juvenile/immunology , Auranofin , Aurothioglucose/therapeutic use , Chemotaxis, Leukocyte/drug effects , Child , Child, Preschool , Chronic Disease , Complement Activation/drug effects , Enzyme-Linked Immunosorbent Assay , Erythrocytes/immunology , Humans , In Vitro Techniques , Neutrophils/immunology , Phagocytosis/drug effects , Time FactorsABSTRACT
The authors consider the presence of streptococcus of group B in the vaginal flora of the medical and paramedical staff who work at the Obstetrical and Gynaecological Clinic and at the Department of Neonatology at the S. Matteo Polyclinic. The identification of fellows (6 cases, 6.8%) colonized by GBS improves the hypothesis of the possibility of a hospital-transmission of the microorganism , and this transmission explains the possible bacterial colonization of newborns, whose mothers are GBS negative. The importance of such a type of transmission has to be referred overall to the possible onset of a neonatal meningitis, in regard to its mortality (20-30%) and to the neurological complications, which can be observed in the child even later on.
