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1.
Schweiz Med Wochenschr ; 113(49): 1845-6, 1983 Dec 10.
Article in German | MEDLINE | ID: mdl-6374884

ABSTRACT

24 hypertensive patients were treated with 300-450 mg tiapamil daily for 2-6 months. The antihypertensive effect of this new calcium entry blocking agent was expressed by a reduction even of extremely elevated blood pressures to the normotensive, but not to the hypotensive range, in 20 patients. The drug was well tolerated.


Subject(s)
Hypertension/drug therapy , Propylamines/therapeutic use , Adult , Aged , Clinical Trials as Topic , Drug Tolerance , Female , Heart Rate/drug effects , Humans , Male , Middle Aged , Tiapamil Hydrochloride
5.
Experientia ; 32(6): 729-30, 1976 Jun 15.
Article in English | MEDLINE | ID: mdl-133031

ABSTRACT

The hyperthermic effect of a bacterial pyrogen has been studied in rabbits pretreated or not with p-chlorophenylalanine or 5, 6-dihydroxytryptamine. The results obtained indicate that a selective reduction of cerebral 5-hydroxytryptamine levels by these drugs do not significantly affect pyrogen hypertermia.


Subject(s)
5,6-Dihydroxytryptamine/pharmacology , Body Temperature/drug effects , Fenclonine/pharmacology , Pyrogens/pharmacology , Tryptamines/pharmacology , Animals , Brain/drug effects , Brain/metabolism , Dopamine/metabolism , Hypothalamus/drug effects , Hypothalamus/metabolism , Male , Norepinephrine/metabolism , Rabbits , Serotonin/metabolism
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