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1.
Unfallchirurg ; 114(1): 35-40, 2011 Jan.
Article in German | MEDLINE | ID: mdl-21161154

ABSTRACT

The 2008 European Football Championship 2008 (Euro 08) is the largest sporting event ever organized in Switzerland. One million visitors came to the city of Berne during the event and the local airport in Bern/Belp registered 261 extra flights. For each football game there were 33,000 fans in the stadium and 100,000 fans in the public viewing zones.The ambulance corps and the Department of Emergency Medicine (ED) at Inselspital, University Hospital Berne, were responsible for basic medical care and emergency medical management. Injuries and illnesses were analyzed by a standardized score (NACA score). The preparation strategy as well as costs and patient numbers are presented in detail.A total of 30 additional ambulance vehicles were used, 4,723 additional working days (one-third medical professionals) were accumulated, 662 ambulance calls were registered and 240 persons needed medical care (62% Swiss, 28% Dutch and 10% other nationalities). Among those needing treatment 51 were treated in 1 of the 4 city hospitals. No injuries with NACA grades VI and VII occurred (NACA I: 4, NACA II: 17, NACA III: 16, NACA IV: 10 and NACA V: 4 patients). The city of Berne compensated the Inselspital Bern with a total of 112,603 Euros for extra medical care costs. The largest amount was spent on security measures (50,300 Euros) and medical staff (medical doctors 22,600 Euros, nurses 29,000 Euros). Because of the poor weather and the exemplary behavior of the fans, the course of events was rather peaceful.


Subject(s)
Disaster Medicine/statistics & numerical data , Emergency Medical Services/statistics & numerical data , Football/statistics & numerical data , Wounds and Injuries/epidemiology , Wounds and Injuries/therapy , Anniversaries and Special Events , Disaster Medicine/economics , Emergency Medical Services/economics , Europe , Humans , Switzerland/epidemiology , Wounds and Injuries/economics
2.
Drug Metab Dispos ; 26(3): 193-6, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9492379

ABSTRACT

Thiodiglycolic acid has been identified as a major metabolite of the anticancer drug ifosfamide in humans. Patients treated with 12-16 g ifosfamide/m2.day excreted thiodiglycolic acid ranging from 0.10 +/- 0.02 mmol on the first day of therapy, to a maximum of 3.27 +/- 0.15 mmol on the fourth day of ifosfamide infusion. This amounted to 5.4 +/- 0.2% of the administered dose of ifosfamide appearing as thiodiglycolic acid in urine during a 5 days' continuous ifosfamide infusion. Thiodiglycolic acid (50mg/kg) administered to rats inhibited the carnitine-dependent oxidation of [1-14C]palmitic acid by 55%, but affected neither the oxidation of [1-14C]octanoic acid, which is carnitine-independent, nor the oxidation of [1, 4-14C]succinic acid, a marker of Kreb's cycle activity. Additionally, thiodiglycolic acid (30 microM) inhibited oxidation of palmitic acid but not palmitoyl-L-carnitine in isolated rat liver mitochondria, indicating that it either sequesters carnitine or inhibits carnitine palmitoyltransferase I. This study elucidates a specific mitochondrial dysfunction induced by thiodiglycolic acid which may contribute to the adverse effects associated with ifosfamide chemotherapy.


Subject(s)
Ifosfamide/metabolism , Mitochondria, Liver/drug effects , Thioglycolates/pharmacology , Thioglycolates/urine , Animals , Antineoplastic Agents, Alkylating/adverse effects , Antineoplastic Agents, Alkylating/metabolism , Caprylates/metabolism , Carnitine/pharmacology , Carnitine O-Palmitoyltransferase/metabolism , Humans , Ifosfamide/adverse effects , Male , Mitochondria, Liver/enzymology , Palmitic Acid/antagonists & inhibitors , Palmitic Acid/metabolism , Rats , Rats, Wistar , Succinic Acid/metabolism
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