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Sci Rep ; 10(1): 10696, 2020 07 01.
Article in English | MEDLINE | ID: mdl-32612119

ABSTRACT

Basal forebrain modulation of central circuits is associated with active sensation, attention, and learning. While cholinergic modulations have been studied extensively the effect of non-cholinergic basal forebrain subpopulations on sensory processing remains largely unclear. Here, we directly compare optogenetic manipulation effects of two major basal forebrain subpopulations on principal neuron activity in an early sensory processing area, i.e. mitral/tufted cells (MTCs) in the olfactory bulb. In contrast to cholinergic projections, which consistently increased MTC firing, activation of GABAergic fibers from basal forebrain to the olfactory bulb leads to differential modulation effects: while spontaneous MTC activity is mainly inhibited, odor-evoked firing is predominantly enhanced. Moreover, sniff-triggered averages revealed an enhancement of maximal sniff evoked firing amplitude and an inhibition of firing rates outside the maximal sniff phase. These findings demonstrate that GABAergic neuromodulation affects MTC firing in a bimodal, sensory-input dependent way, suggesting that GABAergic basal forebrain modulation could be an important factor in attention mediated filtering of sensory information to the brain.


Subject(s)
Olfactory Bulb/physiology , Olfactory Pathways/physiology , Olfactory Perception/physiology , Smell/physiology , Animals , Channelrhodopsins/metabolism , Cholinergic Neurons/physiology , Female , GABAergic Neurons/physiology , Male , Mice , Mice, Transgenic , Odorants/analysis , Olfactometry/methods , Olfactory Bulb/cytology
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