1.
Naturwissenschaften
; 85(3): 136-8, 1998 Mar.
Article
in English
| MEDLINE
| ID: mdl-9562995
Subject(s)
Hemolymph/physiology , Histamine/pharmacology , Histamine/physiology , Predatory Behavior , Spider Venoms/toxicity , Taurine/pharmacology , Taurine/physiology , Animals , Arthropods , Crustacea , Diptera , Drug Synergism , Lethal Dose 50 , Mice , Spiders
2.
J Chromatogr B Biomed Appl
; 658(1): 93-101, 1994 Aug 05.
Article
in English
| MEDLINE
| ID: mdl-7952136
ABSTRACT
A method has been developed for the measurement of zatebradine (UL-FS 49), a heart-rate lowering drug, suitable for the treatment of stable angina pectoris. The method comprises a fully automated liquid-solid extraction using a Zymark Benchmate, a capillary gas chromatography and ammonia chemical ionisation (CI) mass spectrometry using hexadeuterated zatebradine for the internal standard. The assay has a mean between-batch imprecision of 4.9% and a mean inaccuracy of 1.5%. The calibration curve covers the range of 1-30 ng/ml. About 60 samples can be handled per day. The assay has been successfully applied to human pharmacokinetic studies.
Subject(s)
Autoanalysis , Benzazepines/blood , Cardiovascular Agents/blood , Chromatography, Gas/methods , Mass Spectrometry/methods , Ammonia , Benzazepines/pharmacokinetics , Calibration , Capillary Action , Cardiovascular Agents/pharmacokinetics , Chromatography, Gas/statistics & numerical data , Deuterium , Drug Stability , Humans , Mass Spectrometry/statistics & numerical data , Quality Control , Sensitivity and Specificity
3.
Biomed Environ Mass Spectrom
; 17(5): 415-6, 1988 Nov.
Article
in English
| MEDLINE
| ID: mdl-3207929
4.
Arzneimittelforschung
; 28(4): 693-7, 1978.
Article
in German
| MEDLINE
| ID: mdl-155458
