Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Antimicrob Agents Chemother ; 54(3): 1323-6, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20065062

ABSTRACT

Antibiotic-induced bacteriolysis exacerbates inflammation and brain damage in bacterial meningitis. Here the quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P < 0.05). In experimental pneumococcal meningitis, daptomycin treatment resulted in more rapid bacterial killing, lower CSF inflammation, and less brain damage than ceftriaxone treatment.


Subject(s)
Anti-Bacterial Agents/pharmacology , Ceftriaxone/pharmacology , Cerebrospinal Fluid/immunology , Daptomycin/pharmacology , Inflammation , Meningitis, Pneumococcal/drug therapy , Animals , Animals, Newborn , Anti-Bacterial Agents/administration & dosage , Ceftriaxone/administration & dosage , Cerebrospinal Fluid/drug effects , Cerebrospinal Fluid/microbiology , Daptomycin/administration & dosage , Disease Models, Animal , Humans , Inflammation/cerebrospinal fluid , Inflammation/drug therapy , Inflammation/microbiology , Meningitis, Pneumococcal/cerebrospinal fluid , Meningitis, Pneumococcal/immunology , Meningitis, Pneumococcal/microbiology , Rats , Rats, Wistar , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...