Laser nanofabrication inside silicon with spatial beam modulation and anisotropic seeding.

Nanofabrication in silicon, arguably the most important material for modern technology, has been limited exclusively to its surface. Existing lithography methods cannot penetrate the wafer surface without altering it, whereas emerging laser-based subsurface or in-chip fabrication remains at greater than 1 µm resolution. In addition, available methods do not allow positioning or modulation with sub-micron precision deep inside the wafer. The fundamental difficulty of breaking these dimensional barriers is two-fold, i.e., complex nonlinear effects inside the wafer and the inherent diffraction limit for laser light. Here, we overcome these challenges by exploiting spatially-modulated laser beams and anisotropic feedback from preformed subsurface structures, to establish controlled nanofabrication capability inside silicon. We demonstrate buried nanostructures of feature sizes down to 100 ± 20 nm, with subwavelength and multi-dimensional control; thereby improving the state-of-the-art by an order-of-magnitude. In order to showcase the emerging capabilities, we fabricate nanophotonics elements deep inside Si, exemplified by nanogratings with record diffraction efficiency and spectral control. The reported advance is an important step towards 3D nanophotonics systems, micro/nanofluidics, and 3D electronic-photonic integrated systems.

High-Efficiency Multilevel Volume Diffraction Gratings inside Silicon.

Silicon (Si)-based integrated photonics is considered to play a pivotal role in multiple emerging technologies, including telecommunications, quantum computing, and lab-chip systems. Diverse functionalities are either implemented on the wafer surface ("on-chip") or recently within the wafer ("in-chip") using laser lithography. However, the emerging depth degree of freedom has been exploited only for single-level devices in Si. Thus, monolithic and multilevel discrete functionality is missing within the bulk. Here, we report the creation of multilevel, high-efficiency diffraction gratings in Si using three-dimensional (3D) nonlinear laser lithography. To boost device performance within a given volume, we introduce the concept of effective field enhancement at half the Talbot distance, which exploits self-imaging onto discrete levels over an optical lattice. The novel approach enables multilevel gratings in Si with a record efficiency of 53%, measured at 1550 nm. Furthermore, we predict a diffraction efficiency approaching 100%, simply by increasing the number of levels. Such volumetric Si-photonic devices represent a significant advance toward 3D-integrated monolithic photonic chips.

The association between vitamin D status and recurrent wheezing.

OBJECTIVE: To investigate association between vitamin D status and recurrent wheezing in infants. METHODS: Thirty infants with recurrent wheezing and 45 healthy, similar aged infants without any history of acute or chronic illness were included in the study. The clinical features of infants were recorded and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. Data analysis was performed using SPSS 13 package program. RESULTS: The mean value of 25 (OH) D vitamin levels were 22.1 ± 8.9 IU/L and 18.8 ± 11 IU/L for the control and recurrent attack group respectively. Seventy-three percent of subjects with recurrent wheezing had vitamin D levels in the deficient range (<20 ng/ml) and 48.9 % had vitamin D levels under < 20 ng/ml in the control group. The percentage of insufficient vitamin D levels (<30 ng/ml) were 90 and 77.8 for the patient and control group respectively. Eight patients had extremely deficient vitamin D (<10 ng/ml) levels. There was no statistical significance between the groups in terms of the distribution of 25 (OH)D level. CONCLUSIONS: The present study did not demonstrate significant association between vitamin D status and recurrent wheezing in the infants.