[The clinico-pathogenetic variants in the late sequelae of closed brain trauma]. / Kliniko-patogeneticheskie varianty otdalennykh posledstvii zakrytoi travmy golovnofo mozga.

To study clinical manifestations and pathogenetic mechanisms of long-term consequences of closed brain injury, 244 patients with a history of cerebral injury of varying severity were examined. For instrumental and laboratory verification of injury use was made of straight craniography, pneumoencephalography, computer-aided tomography, electroencephalography, rheoencephalography, psychophysiological techniques, immunological examination of the blood and CSF biochemistry. Comparative information content of the different research methods was defined. Broad clinical polymorphism and definite specificity of the manifestations of the consequences of closed braid injury of varying severity in decompensation were revealed. The role of immunological disorders (lowering of suppressor influences of T lymphocytes, elevation of the degree of autoneurosensitization) detectable in 87% of cases was established as was the importance of changes in the correlation of the main neuromediators of the CSF in the formation of the pathogenetically multilevel process of the traumatic disease of the brain.