ABSTRACT
In the dog under anesthesia by pentobarbital, the acute hypertension by depressor buffer nerves section does not develop after adrenalectomy, hypophysectomy or thyroïdectomy. But this type of acute pressor response does appear normal in the dog parathyroïdectomized, splanchnicectomized or with hypothalamic diabetes insipidus.
Subject(s)
Denervation , Diabetes Insipidus/physiopathology , Hypertension/physiopathology , Peripheral Nerves/physiopathology , Adrenalectomy , Animals , Dogs , Hypophysectomy , Parathyroid Glands/physiology , Splanchnic Nerves/physiology , ThyroidectomySubject(s)
Diuresis/drug effects , Sodium/pharmacology , Water/pharmacology , Animals , Carbamazepine/pharmacology , Carisoprodol/pharmacology , Chlorpropamide/pharmacology , Clofibrate/pharmacology , Dogs , Female , Lypressin/pharmacology , Male , Potassium/metabolism , Propranolol/pharmacology , Sodium/metabolismSubject(s)
Hypothalamo-Hypophyseal System/physiology , Pituitary Gland, Posterior/metabolism , Vasopressins/metabolism , Adrenal Glands/physiology , Animals , Aorta/innervation , Blood Volume , Carotid Arteries/innervation , Diabetes Insipidus/physiopathology , Heart Atria/innervation , Humans , Neurons/drug effects , Paraventricular Hypothalamic Nucleus/metabolism , Portal System/innervation , Saline Solution, Hypertonic/pharmacology , Secretory Rate/drug effects , Sensory Receptor Cells/physiology , Stimulation, Chemical , Stress, Physiological/physiopathology , Supraoptic Nucleus/metabolism , Thirst , Water-Electrolyte BalanceABSTRACT
In the dog, the intra-venous injection of practolol (1 to 3 mg/kg) reduces the hypertension provoked by vagotomy and sino-aortic nerves section, or by intra-venous administration of potassium cyanide. But practolol differs from propranolol ; he does not modify hypertension observed after electrical stimulation of central end of saphene, laryngeal superior, or vagus nerf.
Subject(s)
Hypertension/drug therapy , Practolol/therapeutic use , Animals , Blood Pressure/drug effects , Carotid Arteries , Carotid Sinus/physiology , Cyanides , Dogs , Electrocardiography , Female , Femoral Nerve/physiology , Glossopharyngeal Nerve/physiology , Hypertension/chemically induced , Laryngeal Nerves/physiology , Male , Phrenic Nerve/physiology , Propranolol/pharmacology , Vagus Nerve/physiologyABSTRACT
The authors have studied in the dog--normal or diabetic insipidus after hypothalamic lesion--submitted to oral ingestion of ethanol the effects of a few antidiuretic drug: chlorpropamid, atromid-S, carbamazepin and carisoprodol. The carisoprodol only can reduce the diuresis and the drinking provoked by ethanol.