ABSTRACT
Adult T-cell acute lymphoblastic leukemia (T-ALL) continues to represent an unfavorable disease. Molecularly based treatment stratifications could help improve outcome. The prognostic impact of HOX11 and HOX11L2 expression has been an area of controversy. We have investigated 286 adult T-ALL patients enrolled into the German Multicenter ALL (GMALL) therapy protocols by comparative real-time RT-PCR. High HOX11 expression and HOX11L2 expression were predominantly seen in thymic T-ALL (PSubject(s)
Homeodomain Proteins/genetics
, Leukemia-Lymphoma, Adult T-Cell/genetics
, Proto-Oncogene Proteins/genetics
, Thymus Gland/pathology
, Adolescent
, Adult
, Aged
, Female
, Homeodomain Proteins/metabolism
, Humans
, Leukemia-Lymphoma, Adult T-Cell/metabolism
, Leukemia-Lymphoma, Adult T-Cell/pathology
, Male
, Middle Aged
, Prognosis
, Proto-Oncogene Proteins/metabolism
, RNA, Messenger/genetics
, RNA, Messenger/metabolism
, Retrospective Studies
, Reverse Transcriptase Polymerase Chain Reaction
, Risk Factors
, Survival Rate
, Thymus Gland/metabolism
, Treatment Outcome