ABSTRACT
The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
Subject(s)
COVID-19 , Lung Diseases, Interstitial , Humans , COVID-19/complications , Autopsy , Lung Diseases, Interstitial/complications , Lung Diseases, Interstitial/pathologyABSTRACT
A 68-year-old man visited a physician with a chief complaint of difficulty breathing. Right pleural effusion was noted, and he was referred to our department for a close examination and treatment. Thoracoscopy was performed under local anesthesia, and pleural dissemination of lung adenocarcinoma was noted, so a chest drain was placed. Since poor right lung inflation persisted and whole right lung torsion was observed on computed tomography, thoracoscopy-assisted thoracotomic reduction of lung torsion was performed. In this patient, the right middle lobe and anterior chest wall were adhered, suggesting that whole right lung torsion occurred when atelectasis was formed due to pleural effusion.
Subject(s)
Adenocarcinoma of Lung , Lung Neoplasms , Pleural Effusion , Adenocarcinoma of Lung/complications , Adenocarcinoma of Lung/diagnostic imaging , Aged , Humans , Lung , Lung Neoplasms/complications , Lung Neoplasms/diagnostic imaging , Male , Pleural Effusion/diagnostic imaging , Pleural Effusion/etiology , Torsion Abnormality/complications , Torsion Abnormality/diagnostic imaging , Torsion Abnormality/surgeryABSTRACT
The patient was a 75-year-old man who developed polyopia and exophthalmos. Chest computed tomography (CT) revealed a mass in the left upper lobe. A CT-guided biopsy suggested lung adenocarcinoma. He was treated by neoadjuvant chemotherapy followed by left upper lobectomy. He was diagnosed with stage IIB pleomorphic carcinoma postoperatively. Preoperative head magnetic resonance imaging revealed exophthalmos and bilateral swelling of the extraocular muscles. The thyroid function of the patient was within the normal range, and he tested negative for autoantibodies. As his symptoms and swelling of the extraocular muscles improved postoperatively, he was diagnosed with paraneoplastic syndrome.
