1.
Chem Commun (Camb)
; 54(13): 1591-1594, 2018 Feb 08.
Article
in English
| MEDLINE
| ID: mdl-29368774
ABSTRACT
Photopharmaceuticals can, in principle, be created by linking photoswitchable moieties to bioactive molecules. However, a general strategy for converting a therapeutic agent into its photoswitchable version is not currently available. Herein we propose a generalizable, modular approach for obtaining light controllable bioactive agents by modifying the scaffold of a protein affinity reagent using an azobenzene photoswitch.
Subject(s)
Peptide Fragments/chemistry , Photoaffinity Labels/chemistry , Proto-Oncogene Proteins c-fyn/chemistry , Azo Compounds/chemistry , Azo Compounds/radiation effects , Chymases/antagonists & inhibitors , Cross-Linking Reagents/chemistry , Cross-Linking Reagents/radiation effects , Humans , Peptide Fragments/radiation effects , Photoaffinity Labels/radiation effects , Protein Folding/drug effects , Proto-Oncogene Proteins c-fyn/radiation effects , Sulfanilic Acids/chemistry , Sulfanilic Acids/radiation effects , Ultraviolet Rays
2.
Chem Commun (Camb)
; 51(65): 12981-4, 2015 Aug 21.
Article
in English
| MEDLINE
| ID: mdl-26176021
ABSTRACT
Azonium ions formed by p-amino substituted azo compounds with both ortho- and meta-methoxy substituents exhibit strong absorbance in far-red and near infrared spectral region. The compounds undergo robust photoswitching in aqueous solution and exhibit a range of thermal relaxation rates from 10 µs-100 ms.
