ABSTRACT
Oral carcinogenesis is a multistep process that usually arises in the superficial epithelial layer covering the lining of the body cavities. The early changes in the oral mucosa reflect as oral precancers or oral potentially malignant disorders (OPMD). The most common OPMD are erythroplakia and leukoplakia, with their chances of malignant transformation being approximately 90% and 10%, respectively. The development of epithelial precancers is initiated through changes in nuclear shape, size, and density of cells and overall thickening of the epithelial layer. Conventional oral examination (COE) with white light is the most common technique for detection of malignant changes in the oral cavity. This often poses a diagnostic challenge for the clinicians in differentiation of normal and early malignant changes. Thus, biopsy of the site is the accepted clinical procedure for diagnosis of the lesion. A major hurdle here is to identify visually, the most malignant location for a biopsy. As the selection of a site is subjective, the chosen site may not always be representative of the disease and this often leads to repeated biopsies and discomfort to the patients. A novel device known as OralScan was recently introduced by Sascan Meditech, Thiruvananthapuram, for screening and early detection of oral cancers. The clinical application of the device in different clinical scenarios are discussed in this case series report.
Subject(s)
Mouth Diseases , Mouth Neoplasms , Photochemotherapy , Precancerous Conditions , Humans , Leukoplakia, Oral/diagnosis , Leukoplakia, Oral/pathology , Photochemotherapy/methods , Photosensitizing Agents , Mouth Neoplasms/diagnosis , Mouth Neoplasms/pathology , Precancerous Conditions/diagnosis , Precancerous Conditions/pathology , Mouth Diseases/pathology , Mouth Mucosa/pathologyABSTRACT
We report the 4.25-Mbp first draft sequence of Gammaproteobacteria strain MFB021, a moderate halophile isolated from petroleum-contaminated soil in Cochin, India. The genome of the strain MFB021 was sequenced to understand the mechanism of hydrocarbon degradation and the halophilicity of the bacterium.
ABSTRACT
Mangrovibacter sp. MFB070, a Gram-negative, facultatively anaerobic, nitrogen-fixing bacterium, was isolated from an aquaculture farm in Cochin, India. Here, we report the first draft genome sequence of a member of the genus Mangrovibacter, which may help us to elucidate the evolutionary status of this genus. The draft genome sequence of the Mangrovibacter sp. consists of 5,361,682 bp, encoding 4,971 predicted coding sequences in 57 contigs.
