ABSTRACT
OBJECTIVES: Previous studies have reported an increased risk for epileptic seizures in multiple sclerosis (MS) patients. However, data on the pathogenesis of seizures remain inconclusive. The aim of our study is to evaluate prevalence, clinical and paraclinical features of epileptic attacks in our MS cohort and to search MS-specific risk factors for epileptic seizures. MATERIALS AND METHODS: In this cohort of 428 MS patients, 13 patients were identified with epileptic seizures occurring at any point during the course of MS including at MS onset. As a control group, we selected 26 MS patients without seizures and matched for gender, age and date of MS onset. We compared demographic features and clinic-radiological findings between the both groups. RESULTS: Thirteen patients (3%) were identified as having epileptic attacks. Ten patients (77%) experienced focal seizures, half of whom had confirmed secondary generalization. We did not find an association between seizures and disease course. Most patients had a single or few (2-5) seizures. MS patients with seizures had a significantly higher number of cortical and juxtacortical lesions on T2-weighted/fluid attenuation inversion recovery magnetic resonance imaging than control group [OR = 2.6 CI95% (1.0-6.5); P = 0.047]. CONCLUSIONS: Our findings support a credible role of cortical and juxtacortical involvement in the development of epileptic seizures in MS.
Subject(s)
Cerebral Cortex/pathology , Epilepsy/epidemiology , Multiple Sclerosis/complications , Multiple Sclerosis/pathology , Adult , Case-Control Studies , Cerebral Cortex/physiopathology , Cohort Studies , Electroencephalography , Epilepsy/diagnosis , Epilepsy/therapy , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Multiple Sclerosis/physiopathology , Prevalence , Risk FactorsABSTRACT
A patient, without significant previous medical history, who started with diplopia and left palpebral ptosis as the first manifestation of hypophysary metastases of a widely disseminated and previously undetected cancer of pulmonary origin. Together with a histological study of the lesions, the diagnosis was made with specific image tests of the hypophysary area, which detected a neoformation in the sella turca that was invading the left cavernous sinus with erosion of the verso of the sellar, together with the presence of pulmonary nodules and numerous adenopathies. An hypogonadotropic hypogonadism was detected as the only hormonal alteration due to the infiltration of the anterior hypophysis due to the osseous metastases at the base of the cranium. The patient, in spite of receiving several weeks of radiotherapy, suffered a progressive neurological deterioration and died after a few weeks.
Subject(s)
Adenocarcinoma/complications , Adenocarcinoma/secondary , Blepharoptosis/etiology , Diplopia/etiology , Lung Neoplasms/pathology , Pituitary Neoplasms/complications , Pituitary Neoplasms/secondary , Adenocarcinoma/diagnosis , Humans , Male , Middle Aged , Pituitary Neoplasms/diagnosisABSTRACT
Xanthogranulomas of the choroid plexus is a benign tumour of uncertain etiology, usually asymptomatic. We report a case of symptomatic xanthogranuloma of the left lateral ventricle with edema in adjacent white matter, in a 62-year-old man with seizures.
Subject(s)
Granuloma/pathology , Lateral Ventricles/pathology , Xanthomatosis/pathology , Brain Edema/pathology , Choroid Plexus/pathology , Humans , Male , Middle Aged , Seizures/pathologyABSTRACT
El xantogranuloma del plexo coroideo es un tumorbenigno de etiología incierta, que generalmente esasintomático. Presentamos un caso de xantogranulomadel atrio ventricular izquierdo sintomático con edemade la sustancia blanca adyacente, en un paciente varónde 62 años con crisis comiciales de inicio reciente (AU)
Xanthogranulomas of the choroid plexus is a benigntumour of uncertain etiology, usually asymptomatic.We report a case of symptomatic xanthogranuloma ofthe left lateral ventricle with edema in adyacent whitematter, in a 62-year-old man with seizures (AU)
