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Bioorg Med Chem Lett
; 12(16): 2193-6, 2002 Aug 19.
Article
in English
| MEDLINE
| ID: mdl-12127535
ABSTRACT
Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a totally synthetic liposomal vaccine system, these re-designed lipid A analogues demonstrate potent immune stimulatory properties including antigen specific T-cell activation.