ABSTRACT
We report a case of Zika virus (ZIKV) infection in a patient with diarrhea, fever, synovitis, non-purulent conjunctivitis, and with discreet retro-orbital pain, after returning from Colombia in January 2016. The patient referred several mosquito bites. Presence of ZIKV was detected by PCR (polymerase chain reaction) in plasma. Rapid microbiological diagnosis of ZIKV infection is needed in European countries with circulation of its vector, in order to avoid autochthonous circulation. The recent association of ZIKV infection with abortion and microcephaly, and a Guillain-Barré syndrome highlights the need for laboratory differentiation of ZIKV from other virus infection. Women with potential risk for Zika virus infection who are pregnant or planning to become pregnant must mention that fact during prenatal visits in order to be evaluated and properly monitored
Presentamos un caso de infección por virus Zika (ZIKV) en un paciente con diarrea, fiebre, sinovitis, conjuntivitis no purulenta, con discreto dolor retroorbital, después de regresar de Colombia en enero de 2016. El paciente refería múltiples picaduras de mosquito. La presencia de ZIKV fue detectada en plasma por reacción en cadena de la polimerasa (PCR). En los países europeos en los que exista circulación de su vector es necesario un diagnóstico microbiológico rápido de la infección por ZIKV para evitar transmisión autóctona. La asociación reciente de la infección por ZIKV con abortos y microcefalia y síndrome de Guillén-Barré pone de relieve la necesidad de la diferenciación de ZIKV de otras infecciones por virus. Las mujeres con riesgo potencial de infección por el virus Zika que están embarazadas o que planeen quedar embarazadas deben mencionar esa circunstancia durante las visitas prenatales con el fin de ser evaluadas y monitorizadas adecuadamente
Subject(s)
Humans , Male , Middle Aged , Zika Virus/pathogenicity , Zika Virus Infection/prevention & control , Aedes/pathogenicity , Communicable Diseases, Emerging/epidemiology , Polymerase Chain Reaction/methods , Flavivirus/pathogenicity , Insect VectorsABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Myoclonic Cerebellar Dyssynergia/chemically induced , Myoclonic Cerebellar Dyssynergia/complications , Metronidazole/adverse effects , Linezolid/therapeutic use , Cefotaxime/therapeutic use , Drug-Related Side Effects and Adverse Reactions/diagnosis , Drug-Related Side Effects and Adverse Reactions/prevention & control , Algorithms , Pancytopenia/complications , Pancytopenia/drug therapy , Cerebellar Ataxia/chemically induced , Cerebellar Ataxia/complications , Electromyography/instrumentation , Electromyography/methods , PrognosisABSTRACT
We report a case of Zika virus (ZIKV) infection in a patient with diarrhea, fever, synovitis, non-purulent conjunctivitis, and with discreet retro-orbital pain, after returning from Colombia in January 2016. The patient referred several mosquito bites. Presence of ZIKV was detected by PCR (polymerase chain reaction) in plasma. Rapid microbiological diagnosis of ZIKV infection is needed in European countries with circulation of its vector, in order to avoid autochthonous circulation. The recent association of ZIKV infection with abortion and microcephaly, and a Guillain-Barré syndrome highlights the need for laboratory differentiation of ZIKV from other virus infection. Women with potential risk for Zika virus infection who are pregnant or planning to become pregnant must mention that fact during prenatal visits in order to be evaluated and properly monitored.
Subject(s)
Insect Bites and Stings/virology , Zika Virus Infection/diagnosis , Europe , Humans , Male , Middle Aged , Spain , Travel , Zika VirusSubject(s)
Anti-Bacterial Agents/adverse effects , Cerebellar Ataxia/chemically induced , Dysarthria/chemically induced , Metronidazole/adverse effects , Anti-Bacterial Agents/therapeutic use , Brain Abscess/complications , Brain Abscess/drug therapy , Cefotaxime/therapeutic use , Cephalosporins/therapeutic use , Cerebellar Ataxia/diagnosis , Cerebellar Ataxia/diagnostic imaging , Diagnosis, Differential , Diverticulitis/complications , Diverticulitis/drug therapy , Drug Therapy, Combination , Humans , Linezolid/therapeutic use , Liver Abscess/complications , Liver Abscess/drug therapy , Lung Abscess/complications , Lung Abscess/drug therapy , Magnetic Resonance Angiography , Male , Metronidazole/therapeutic use , Middle Aged , Paraneoplastic Syndromes/diagnosis , Vasculitis/diagnosisABSTRACT
No disponible
Subject(s)
Humans , Duodenitis/diagnosis , Ischemia/physiopathology , ComorbiditySubject(s)
Duodenitis/etiology , Duodenum/blood supply , Ischemia/complications , Abdominal Pain/etiology , Aged , Comorbidity , Diabetes Complications , Duodenal Ulcer/etiology , Duodenal Ulcer/pathology , Duodenitis/pathology , Duodenum/pathology , Fatal Outcome , Female , Humans , Hypertension/complications , Ischemia/diagnosis , Kidney Failure, Chronic/complications , Melena/etiology , Myocardial Ischemia/complications , Pulmonary Disease, Chronic Obstructive/complicationsABSTRACT
OBJECTIVES: Access to antiretroviral treatment (ART) has become essential to delay HIV clinical progression and increase survival, so improving Health Related Quality of Life (HRQL). The aim of this investigation was to describe factors associated with ART and their impact on HRQL in HIV infected patients. METHODS: A cross-sectional study on 150 HIV-outpatients in a tertiary hospital was designed, and ART-related data collected. Adherence was assessed by the SMAQ questionnaire. HRQL data were collected by disease-specific questionnaire MOS-HIV (Medical Outcomes Study HIV Health Survey). RESULTS: A total of 84% of patients were on ART. Half of the treatment regimens were Protease inhibitor (PI) based, LPV/r being the most commonly used drug. The large majority of treatments used (89.7%) were second line or successive, and NNRTI-based combinations were the most used in first line. Lipodystrophy was the most frequently referred side-effect (61.1%). Almost all (94.5%) of our patients declared they were adapting well to treatment in their daily-life-activities, with 64.3% adhering to treatment according to the SMAQ (Simplified Medication Adherence Questionnaire) questionnaire. In the HRQL, patients with PI-based treatment got lower scores in 4 of 11 domains with the MOS-HIV questionnaire; while patients that adapted well to their ART had better scores in 4 of 11 domains and overall HRQL assessment in MOS-HIV. CONCLUSIONS: Most of our patients were on ART during our investigation. We have documented a negative association between PI-based treatment and HRQL domains, and a positive association between subjective ART adaptation and HRQL. The assessment of HRQL in this population has increasing interest as it is influenced by ART related factors as treatment improves life conditions of HIV infected people.
Subject(s)
Anti-Retroviral Agents/therapeutic use , HIV Infections/drug therapy , Quality of Life , Adult , Cross-Sectional Studies , Female , Humans , MaleABSTRACT
Objetivo El acceso al tratamiento antirretroviral (TARV) retrasa la progresión clínica del VIH y aumenta la supervivencia, mejorando la calidad de vida relacionada con la salud (CVRS). El objetivo de nuestra investigación fue describir los factores asociados al TARV y su influencia en la CVRS en personas infectadas por VIH. Material y método Se diseñó un estudio transversal en 150 pacientes con VIH de un hospital de tercer nivel, recogiéndose datos relativos al TARV. La adherencia se valoró con el cuestionario SMAQ (Simplified Medication Adherence Questionnaire). Los datos de CVRS se obtuvieron con el cuestionario MOS-HIV (Medical Outcomes Study HIV Health Survey).Resultados El 84% de nuestros pacientes estaban en TARV. La mitad de las pautas se basaban en inhibidores de la proteasa (IP), siendo LPV/r el fármaco de este grupo más empleado. En el 89,7% el régimen era el segundo o sucesivo, y la combinación basada en no análogos la más empleada en el tratamiento de primera línea. La lipodistrofia fue el efecto secundario más referido (61,1%). El 94,5% adaptaba bien el TARV a su vida diaria, siendo adherentes el 64,3%, según el cuestionario SMAQ. En cuanto a la CVRS, los pacientes con IP obtuvieron peores puntuaciones en 4 de las 11 dimensiones del cuestionario MOS-HIV. Los pacientes que dijeron adaptar bien el TARV presentaron mejores puntuaciones en 4 de las 11 dimensiones y en la valoración global del MOS-HIV. Conclusiones La prevalencia de pacientes en TARV en nuestra serie fue alta, habiéndose documentado relación negativa entre la toma de IP y CVRS, y positiva entre adaptación subjetiva del TARV y CVRS. La valoración de la CVRS en estos pacientes es importante, ya que se ve influida por factores relativos al TARV, dado que este mejora las condiciones vitales de las personas infectadas por VIH (AU)
Objectives Access to antiretroviral treatment (ART) has become essential to delay HIV clinical progression and increase survival, so improving Health Related Quality of Life (HRQL). The aim of this investigation was to describe factors associated with ART and their impact on HRQL in HIV infected patients. Methods A cross-sectional study on 150 HIV-outpatients in a tertiary hospital was designed, and ART-related data collected. Adherence was assessed by the SMAQ questionnaire. HRQL data were collected by disease-specific questionnaire MOS-HIV (Medical Outcomes Study HIV Health Survey).Results A total of 84% of patients were on ART. Half of the treatment regimens were Protease inhibitor (PI) based, LPV/r being the most commonly used drug. The large majority of treatments used (89.7%) were second line or successive, and NNRTI-based combinations were the most used in first line. Lipodystrophy was the most frequently referred side-effect (61.1%). Almost all (94.5%) of our patients declared they were adapting well to treatment in their daily-life-activities, with 64.3% adhering to treatment according to the SMAQ (Simplified Medication Adherence Questionnaire) questionnaire. In the HRQL, patients with PI-based treatment got lower scores in 4 of 11 domains with the MOS-HIV questionnaire; while patients that adapted well to their ART had better scores in 4 of 11 domains and overall HRQL assessment in MOS-HIV. Conclusions Most of our patients were on ART during our investigation. We have documented a negative association between PI-based treatment and HRQL domains, and a positive association between subjective ART adaptation and HRQL. The assessment of HRQL in this population has increasing interest as it is influenced by ART related factors as treatment improves life conditions of HIV infected people (AU)
Subject(s)
Humans , Anti-Retroviral Agents/pharmacokinetics , HIV Infections/drug therapy , Protease Inhibitors/pharmacokinetics , Quality of Life , Risk FactorsSubject(s)
Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/therapeutic use , Drug Prescriptions/statistics & numerical data , Drug Prescriptions/standards , Hospital Units/statistics & numerical data , Internal Medicine , Adult , Aged , Aged, 80 and over , Bacterial Infections/drug therapy , Bacterial Infections/microbiology , Drug Interactions , Drug Utilization , Female , Humans , Male , Middle Aged , Retrospective Studies , Young AdultSubject(s)
Humans , Male , Female , Middle Aged , Drug Interactions/physiology , Drug Prescriptions/standards , Internal Medicine/methods , Internal Medicine/trends , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/metabolism , Anti-Bacterial Agents/pharmacology , /complications , /diagnosis , Cross-Sectional StudiesSubject(s)
Brachyspira/isolation & purification , Colitis/complications , Diarrhea/etiology , Gram-Negative Bacterial Infections/complications , HIV Infections/complications , Adult , Colitis/diagnosis , Colitis/drug therapy , Colitis/microbiology , Colonoscopy , Gram-Negative Bacterial Infections/diagnosis , Gram-Negative Bacterial Infections/drug therapy , Homosexuality , Humans , Intestinal Mucosa/microbiology , Intestinal Mucosa/ultrastructure , Male , Microvilli/microbiology , Microvilli/ultrastructure , Penicillin G/therapeutic use , Syphilis, Latent/complications , Syphilis, Latent/diagnosis , Syphilis, Latent/drug therapySubject(s)
Humans , Male , Adult , Brachyspira/isolation & purification , Colitis/complications , Colitis/microbiology , Diarrhea/microbiology , Gram-Negative Bacterial Infections/complications , Gram-Negative Bacterial Infections/microbiology , HIV Infections/complications , Intestinal Mucosa/microbiology , Intestinal Mucosa/ultrastructure , Homosexuality, Male , Colitis/diagnosis , Colitis/drug therapy , Colonoscopy , Gram-Negative Bacterial Infections/diagnosis , Gram-Negative Bacterial Infections/drug therapySubject(s)
Antitubercular Agents/adverse effects , Isoniazid/adverse effects , Pancreatitis/chemically induced , Acute Disease , Aged, 80 and over , Antitubercular Agents/therapeutic use , Drug Therapy, Combination , Female , Femoral Neck Fractures/drug therapy , Femoral Neck Fractures/etiology , Fractures, Spontaneous/drug therapy , Fractures, Spontaneous/etiology , Humans , Isoniazid/therapeutic use , Pyrazinamide/therapeutic use , Rifampin/therapeutic use , Tuberculosis, Osteoarticular/drug therapy , Tuberculosis, Osteoarticular/etiologyABSTRACT
No disponible
Subject(s)
Female , Aged, 80 and over , Humans , Antitubercular Agents/adverse effects , Isoniazid/adverse effects , Isoniazid/therapeutic use , Pancreatitis/chemically induced , Acute Disease , Antitubercular Agents/therapeutic use , Drug Combinations , Femoral Neck Fractures/drug therapy , Femoral Neck Fractures/etiology , Fractures, Spontaneous/drug therapy , Fractures, Spontaneous/etiology , Pyrazinamide/therapeutic use , Rifampin/therapeutic use , Tuberculosis, Osteoarticular/drug therapy , Tuberculosis, Osteoarticular/etiologyABSTRACT
No disponible
Subject(s)
Aged , Female , Humans , Myocardial Ischemia , Piperidines , Cholinesterase Inhibitors , IndansABSTRACT
No disponible
