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1.
Teach Learn Med ; : 1-13, 2024 Apr 05.
Article in English | MEDLINE | ID: mdl-38577850

ABSTRACT

Phenomenon: Shared decision making (SDM) is a core ideal in the interaction between healthcare providers and patients, but the implementation of the SDM ideal in clinical routines has been a relatively slow process. Approach: In a sociological study, 71 interactions between physicians and simulated patients enacting chronic heart failure were video-recorded in China, Germany, the Netherlands, and Turkey as part of a quasi-experimental research design. Participating physicians varied in specialty and level of experience. The secondary analysis presented in this article used content analysis to study core components of SDM in all of the 71 interactions and a grounded theory approach to observe how physicians responded actively to patients even though they did not actively employ the SDM ideal. Findings: Full realization of the SDM ideal remains an exception, but various aspects of SDM in physician-patient interaction were observed in all four locations. Analyses of longer interactions show dynamic processes of interaction that sometimes surprised both patient and physician. We observed varieties of SDM that differ from the SDM ideal but arguably achieve what the SDM ideal is intended to achieve. Our analysis suggests a need to revisit the SDM ideal-to consider whether varieties of SDM may be acceptable, even valuable, in their own right. Insights: The gap between the SDM ideal and SDM as implemented in clinical practice may in part be explained by the tendency of medicine to define and teach SDM through a narrow lens of checklist evaluations. The authors support the argument that SDM defies a checklist approach. SDM is not uniform, but nuanced, dependent on circumstances and setting. As SDM is co-produced by patients and physicians in a dynamic process of interaction, medical researchers should consider and medical learners should be exposed to varieties of SDM-related practice rather than a single idealized model. Observing and discussing worked examples contributes to the physician's development of realistic expectations and personal professional growth.

2.
Sociol Health Illn ; 45(5): 1101-1122, 2023 06.
Article in English | MEDLINE | ID: mdl-36998218

ABSTRACT

The biomedical approach to medical knowledge is widely accepted around the world. This article considers whether the incorporated aspects of physician-patient interaction have become similarly common across the globe by comparing the gestures that physicians use in their interactions with patients. Up to this point, there has been little research on physicians' use of gestures in health-care settings. We explore how-in four university hospitals in Turkey, the People's Republic of China, The Netherlands and Germany-physicians use gesture in their discussions with simulated patients about the condition of heart failure. Our analysis confirms the importance of gestures for organising both the personal interaction and the knowledge transfer between physician and patient. From the perspective of global comparison, it is notable that physicians in all four hospitals used similar gestures. This demonstrates the globality of biomedical knowledge in an embodied mode. Physicians used gestures for a range of purposes, including to convey the idea of an 'anatomical map' and for constructing visual models of (patho-)physiological processes. Since biomedical language is rife with metaphor, it was not surprising that we also identified an accompanying metaphorical gesture which has a similar form in the various locations that were part of the study.


Subject(s)
Heart Failure , Physicians , Humans , Gestures , Language , Metaphor
3.
Patient Educ Couns ; 105(7): 2320-2327, 2022 07.
Article in English | MEDLINE | ID: mdl-34887158

ABSTRACT

OBJECTIVE: To present a guide for communication curriculum development in healthcare professions for educators and curriculum planners. METHODS: We collated a selection of theories, frameworks and approaches to communication curriculum development to provide a roadmap of the main factors to consider when developing or enhancing communication skills curricula. RESULTS: We present an evidence-based guide for developing and enhancing communication curriculum that can be applied to undergraduate and postgraduate healthcare education. Recommended steps to consider during the communication curricula development process include thoughtful examination of current communication education, needs assessment, focused learning goals and objectives, incorporation of experiential educational strategies allowing for skills practice and feedback and use of formative and summative assessment methods. A longitudinal, developmental and helical implementation approach contributes to reinforcement and sustainment of learners' knowledge and skills. CONCLUSION AND PRACTICE IMPLICATIONS: Drawing on best practices in developing communication curricula can be helpful in ensuring successful approaches to communication skills training for any level of learner or healthcare profession. This position paper provides a guide and identifies resources for new and established communication curriculum developers to reflect on strengths and opportunities in their own approaches to addressing the communication education needs of their learners.


Subject(s)
Curriculum , Education, Medical, Undergraduate , Clinical Competence , Communication , Delivery of Health Care , Humans
4.
Patient Educ Couns ; 101(8): 1439-1451, 2018 08.
Article in English | MEDLINE | ID: mdl-29501215

ABSTRACT

OBJECTIVES: Effective instructional approaches are needed to enable undergraduates to optimally prepare for the limited training time they receive with simulated patients (SPs). This study examines the learning effects of different presentation formats of a worked example on student SP communication. METHODS: Sixty-seven fourth-year medical students attending a mandatory communication course participated in this randomized field trial. Prior to the course, they worked through an e-learning module that introduced the SPIKES protocol for delivering bad news to patients. In this module, a single worked example was presented to one group of students in a text version, to a second group in a video version, and to a third group in a video version enriched with text hints denoting the SPIKES steps. RESULTS: The video-with-hints group broke bad news to SPs significantly more appropriately than either of the other groups. Although no further condition-related effects were revealed, students who learned from the text version most frequently (although non-significantly) ignored unpleasant emotions (standardised emotional cues and concerns) expressed by the SPs. CONCLUSIONS: The learning effect was strongest when the video-based worked example was accompanied by hints. PRACTICE IMPLICATIONS: Video-related learning approaches that embed attention-guiding hints can effectively prepare undergraduates for SP encounters.


Subject(s)
Education, Medical, Undergraduate/methods , Learning , Students, Medical/psychology , Truth Disclosure , Clinical Competence , Emotions , Female , Humans , Male , Patient Simulation , Video Recording , Young Adult
5.
Patient Educ Couns ; 100(10): 1874-1881, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28601262

ABSTRACT

OBJECTIVE: To assess students' communication skills during clinical medical education and at graduation. METHODS: We conducted an observational cohort study from 2007 to 2011 with 26 voluntary undergraduate medical students at Hamburg University based on video-taped consultations in year four and at graduation. 176 consultations were analyzed quantitatively with validated and non-validated context-independent communication observation instruments (interrater reliability ≥0.8). Based on observational protocols each consultation was also documented in free-text comments, salient topics were extracted afterwards. RESULTS: 26 students, seven males, were enrolled in the survey. On average, graduates scored higher in differential-diagnostic questioning and time management but showed deficiencies in taking systematic and complete symptom-oriented histories, in communication techniques, in structuring consultations and in gathering the patients' perspectives. Patient-centeredness and empathy were rather low at graduation. Individual deficiencies could barely be eliminated. CONCLUSION: Medical students were able to enhance their clinical reasoning skills and their time management. Still, various communication deficiencies in final year students became evident regarding appropriate history taking, communication skills, empathy and patient-centeredness. PRACTICE IMPLICATIONS: The necessity of developing a longitudinal communication curriculum with enhanced communication trainings and assessments became evident. A curriculum should ensure that students' communication competencies are firmly achieved at graduation.


Subject(s)
Communication , Curriculum , Education, Medical, Undergraduate/methods , Students, Medical , Adult , Clinical Competence , Cohort Studies , Educational Measurement/methods , Female , Humans , Male , Patient Simulation , Videotape Recording
7.
GMS J Med Educ ; 33(2): Doc23, 2016.
Article in English | MEDLINE | ID: mdl-27280134

ABSTRACT

BACKGROUND AND AIM: Communication is object of increasing attention in the health professions. Teaching communication competencies should already begin in undergraduate education or pre-registration training. The aim of this project was to translate the Health Professions Core Communication Curriculum (HPCCC), an English catalogue of learning objectives, into German to make its content widely accessible in the German-speaking countries. This catalogue lists 61 educational objectives and was agreed on by 121 international communication experts. A European reference framework for inter- and multi-professional curriculum development for communication in the health professions in German-speaking countries should be provided. METHOD: The German version of the HPCCC was drafted by six academics and went through multiple revisions until consensus was reached. The learning objectives were paired with appropriate teaching and assessment tools drawn from the database of the teaching Committee of the European Association for Communication Health Care (tEACH). RESULTS: The HPCCC learning objectives are now available in German and can be applied for curriculum planning and development in the different German-speaking health professions, the educational objectives can also be used for inter-professional purposes. Examples for teaching methods and assessment tools are given for using and implementing the objectives. CONCLUSION: The German version of the HPCCC with learning objectives for communication in health professions can contribute significantly to inter- and multi-professional curriculum development in the health care professions in the German-speaking countries. Examples for teaching methods and assessment tools from the materials compiled by tEACH supplement the curricular content and provide suggestions for practical implementation of the learning objectives in teaching and assessment. The relevance of the German HPCCC to the processes of curriculum development for the various health professions and inter-professional approaches should be the subject of further evaluation.


Subject(s)
Communication , Consensus , Curriculum , Education, Medical, Undergraduate , Health Occupations , Humans
8.
GMS Z Med Ausbild ; 32(5): Doc56, 2015.
Article in English | MEDLINE | ID: mdl-26604998

ABSTRACT

OBJECTIVES: Increasingly, communicative competencies are becoming a permanent feature of training and assessment in German-speaking medical schools (n=43; Germany, Austria, Switzerland - "D-A-CH"). In support of further curricular development of communicative competencies, the survey by the "Communicative and Social Competencies" (KusK) committee of the German Society for Medical Education (GMA) systematically appraises the scope of and form in which teaching and assessment take place. METHODS: The iterative online questionnaire, developed in cooperation with KusK, comprises 70 questions regarding instruction (n=14), assessment (n=48), local conditions (n=5), with three fields for further remarks. Per location, two to three individuals who were familiar with the respective institute's curriculum were invited to take part in the survey. RESULTS: Thirty-nine medical schools (40 degree programmes) took part in the survey. Communicative competencies are taught in all of the programmes. Ten degree programmes have a longitudinal curriculum for communicative competencies; 25 programmes offer this in part. Sixteen of the 40 programmes use the Basler Consensus Statement for orientation. In over 80% of the degree programmes, communicative competencies are taught in the second and third year of studies. Almost all of the programmes work with simulated patients (n=38) and feedback (n=37). Exams are exclusively summative (n=11), exclusively formative (n=3), or both summative and formative (n=16) and usually take place in the fifth or sixth year of studies (n=22 and n=20). Apart from written examinations (n=15) and presentations (n=9), practical examinations are primarily administered (OSCE, n=31); WPA (n=8), usually with self-developed scales (OSCE, n=19). With regards to the examiners' training and the manner of results-reporting to the students, there is a high variance. CONCLUSIONS: Instruction in communicative competencies has been implemented at all 39 of the participating medical schools. For the most part, communicative competencies instruction in the D-A-C-H region takes place in small groups and is tested using the OSCE. The challenges for further curricular development lie in the expansion of feedback, the critical evaluation of appropriate assessment strategies, and in the quality assurance of exams.


Subject(s)
Clinical Competence , Communication , Education, Medical, Undergraduate , Reality Testing , Teaching , Austria , Curriculum , Education , Educational Measurement , Germany , Humans , Longitudinal Studies , Patient Simulation , Schools, Medical , Surveys and Questionnaires , Switzerland
9.
J Am Med Dir Assoc ; 15(2): 117-26, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24321877

ABSTRACT

OBJECTIVE: To compare the costs of care for community-dwelling dementia patients with the costs of care for dementia patients living in nursing homes from the societal perspective. DESIGN: Cross-sectional bottom-up cost of illness study nested within the multicenter German AgeCoDe-cohort. SETTING: Community and nursing homes. PARTICIPANTS: One hundred twenty-eight community-dwelling dementia patients and 48 dementia patients living in nursing homes. INTERVENTION: None. MEASUREMENTS: Utilization and costs of medical care and long term care, including formal and informal social and nursing care based on proxy interviews. Informal care was valued using the replacement cost method. RESULTS: Unadjusted mean annual total costs including informal care were €29,930 ($43,997) for community-dwelling patients and €33,482 ($49,218) for patients living in nursing homes. However, multiple regression analysis controlling for age, sex, deficits in basic and instrumental activities of daily living and comorbidity showed that living in the community significantly increased total costs by €11,344 ($16,676; P < .01) compared with living in a nursing home, mainly due to higher costs of informal care (+€20,585; +$30,260; P < .001). CONCLUSION: From the societal perspective care for dementia patients living in the community tends to cost more than care in nursing homes when functional impairment is controlled for.


Subject(s)
Caregivers/economics , Dementia/economics , Home Care Services/economics , Nursing Homes/economics , Activities of Daily Living , Aged , Aged, 80 and over , Ambulatory Care/economics , Ambulatory Care/statistics & numerical data , Cross-Sectional Studies , Dementia/epidemiology , Disability Evaluation , Female , Germany/epidemiology , Home Care Services/statistics & numerical data , Hospitalization/economics , Hospitalization/statistics & numerical data , Humans , Male , Regression Analysis , Severity of Illness Index
10.
Am J Geriatr Psychiatry ; 22(10): 1017-28, 2014 Oct.
Article in English | MEDLINE | ID: mdl-23759289

ABSTRACT

OBJECTIVES: To establish the diagnostic accuracy of the Total Score of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological assessment battery (CERAD-NP) both for cross-sectional discrimination of Alzheimer disease (AD) dementia and short-term prediction of incident AD dementia. DESIGN: Longitudinal cohort study with two assessments at a 1.5-year interval. SETTING: Primary care sample randomly recruited via medical record registries. PARTICIPANTS: As part of the German Study on Ageing, Cognition, and Dementia (AgeCoDe), a sample of elderly individuals (N = 1,606; mean age: 84 years) was assessed. MEASUREMENTS: Subjects were assessed with the CERAD-NP and followed up for 18 months (97.6% follow-up rate). Logistic regression and receiver-operating-characteristic (ROC) curve analysis were used to compare the diagnostic accuracy of the CERAD-NP Total Score (CTS) with that of single CERAD-NP scores and the Mini-Mental-State-Examination (MMSE) score. RESULTS: ROC curve analysis resulted in excellent (area under the curve [AUC]: 0.97) cross-sectional discrimination between non-AD and AD dementia subjects. Prediction of incident AD dementia with the CTS was also very good (AUC: 0.89), and was significantly better than prediction based on the MMSE. CONCLUSIONS: The cross-sectional results confirm that the CTS is a highly accurate diagnostic tool for detecting AD dementia in elderly primary care patients. In addition, we provide evidence that the CTS is also accurate for the prediction of incident AD dementia. These findings further support the validity of the CTS as an index of overall cognitive functioning for detection and prediction of AD dementia.


Subject(s)
Alzheimer Disease/diagnosis , Neuropsychological Tests/standards , Predictive Value of Tests , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Germany , Humans , Longitudinal Studies , Male , ROC Curve , Regression Analysis
11.
PLoS One ; 8(7): e70018, 2013.
Article in English | MEDLINE | ID: mdl-23875017

ABSTRACT

OBJECTIVE: To analyse predictors of costs in dementia from a societal perspective in a longitudinal setting. METHOD: Healthcare resource use and costs were assessed retrospectively using a questionnaire in four waves at 6-month intervals in a sample of dementia patients (N = 175). Sociodemographic data, dementia severity and comorbidity at baseline, cognitive impairment and impairment in basic and instrumental activities of daily living were also recorded. Linear mixed regression models with random intercepts for individuals were used to analyse predictors of total and sector-specific costs. RESULTS: Impairment in activities of daily living significantly predicted total costs in dementia patients, with associations between basic activities of daily living and formal care costs on the one and instrumental activities of daily living and informal care costs on the other hand. Nursing home residence was associated with lower total costs than residence in the community. There was no effect of cognition on total or sector-specific costs. CONCLUSION: Cognitive deficits in dementia are associated with costs only via their effect on the patients' capacity for activities of daily living. Transition into a nursing home may reduce total costs from a societal perspective, owing to the fact that a high amount of informal care required by severely demented patients prior to transition into a nursing home may cause higher costs than inpatient nursing care.


Subject(s)
Dementia/economics , Health Resources/economics , Activities of Daily Living , Cognition Disorders/pathology , Comorbidity , Dementia/pathology , Germany , Humans , Regression Analysis , Retrospective Studies , Surveys and Questionnaires
12.
Patient Educ Couns ; 93(2): 298-305, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23806818

ABSTRACT

OBJECTIVE: To pilot-test feasibility, acceptance and learning-outcomes of a brief interdisciplinary communication skills training program in undergraduate medical education. METHODS: A two-hour interdisciplinary communication skills program with simulated patients was developed and pilot-tested with clinical students at Hamburg University. Five psychosocial specialties facilitated the training. Composite effects were measured qualitatively and quantitatively. RESULTS: Eighty students volunteered to participate in the pilot-program (intervention-group). Their evaluations of the program were very positive (1.1 on a six-point scale). Benefits were seen in feedback, increase of self-confidence, cross-disciplinary clinical and communication experience. Students who did not volunteer (n=206) served as the control-group. The intervention-group performed significantly better (p=0.023) in a primary care communication examination and female students performed better than males. Clinical teachers evaluated the pilot-training very positively with regard to learning-outcomes and feasibility. The positive results from the pilot-training led to implementation into the regular curriculum. CONCLUSIONS: A two-hour interdisciplinary communication skills training program is beneficial for medical students with regard to communication competencies, self-confidence and learning-outcomes. PRACTICE IMPLICATION: The training is feasible within given time-frames and limited staff resources. The high teaching load for small-group-training are split between five specialties. The concept might be an interesting option for other faculties.


Subject(s)
Education, Medical, Undergraduate/methods , Interdisciplinary Communication , Students, Medical/psychology , Adult , Curriculum , Educational Measurement , Female , Humans , Male , Patient Simulation , Pilot Projects
13.
J Affect Disord ; 150(1): 63-9, 2013 Aug 15.
Article in English | MEDLINE | ID: mdl-23474092

ABSTRACT

BACKGROUND: Depression is a risk factor for stroke and mortality but whether this also holds into old age is uncertain. We therefore studied the association of depression with the risk for non-fatal stroke and all-cause mortality in very old age. METHODS: A representative sample of 3085 primary care patients aged ≥ 75 years were serially assessed during a 6-year follow-up. The relation between depression (Geriatric Depression Scale >6, n=261) and relevant covariates including vascular risk factors and disease, functional and mild cognitive impairment and ApoE genotype on primary care givers information of incident stroke (n=209) and mortality (n=647) were assessed by Cox regression and by competing risk regressions. RESULTS: Depression was not independently associated with incident stroke in fully adjusted models that treated death as the competing event (subdistribution hazard ratio=0.80, 95% confidence interval=0.47 to 1.36). The risk associated with depression was similar for men and women, and for age groups 75-79, 80-84 and ≥ 85 years. In contrast, depression increased all-cause mortality rates, even after adjusting for a range of confounders (hazard ratio=1.31, 95% confidence interval=1.03 to 1.67). LIMITATIONS: We have no information on past depressive episodes and cause of death. CONCLUSIONS: In contrast to reports in younger populations, depression does not appear to increase stroke risk among the old and very old, but continuous to be a risk factor for all-cause mortality.


Subject(s)
Depression/epidemiology , Primary Health Care/statistics & numerical data , Stroke/epidemiology , Age Distribution , Aged , Aged, 80 and over , Cause of Death , Depression/mortality , Female , Follow-Up Studies , Germany/epidemiology , Humans , Incidence , Male , Models, Statistical , Prospective Studies , Risk Factors , Sex Distribution
14.
Age Ageing ; 42(2): 173-80, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23315829

ABSTRACT

OBJECTIVE: to determine incidence and predictors of late-life depression. METHODS: this is a 3-year observational cohort study of 3,214 non-demented patients aged 75 and over completing three waves of assessment. The patients were recruited in 138 primary care practices in six urban areas in Germany. Depressive symptoms were measured at baseline, and 18 months and 36 months later using the GDS-15 Geriatric Depression Scale with a cut-off 0-5/6-15. Cox proportional hazard regression models were applied to examine predictors of incident depression, adjusting for sex, age, education, living situation, activities of daily living - and instrumental activities of daily living impairment, somatic comorbidity, alcohol consumption, smoking, mild cognitive impairment and apoE4 status. RESULTS: the incidence of depression was 36.8 (95% CI: 29.6-45.3) per 1,000 person-years in men and 46.0 (95% CI: 39.9-52.8) in women (sex difference P = 0.069). The incidence increased from 35.4 (95% CI: 29.7-41.9) per 1000 person-years between the ages of 75 and 79 to 75.2 (95% CI: 53.2-103.2) for subjects 85 years and older. After full adjustment for confounding variables, hazard ratios (HR) for incident depression were significantly higher for subjects 85 years and older (HR: 1.83, 95% CI: 1.24-2.70) and those with mobility impairment (HR: 2.53, 95% CI: 1.97-3.25), vision impairment (HR: 1.41, 95% CI: 1.04-1.91), mild cognitive impairment (HR: 1.52, 95% CI: 1.10-2.10), subjective memory impairment (HR: 1.33, 95% CI: 1.01-1.74) and current smoking (HR: 1.69, 95% CI: 1.13-2.53). CONCLUSIONS: the incidence of depression increased significantly with age. In designing prevention programmes, it is important to call more attention on functional impairment, cognitive impairment and smoking.


Subject(s)
Aging/psychology , Depression/epidemiology , Primary Health Care , Age Factors , Aged , Aged, 80 and over , Cognitive Dysfunction/epidemiology , Cognitive Dysfunction/psychology , Comorbidity , Depression/diagnosis , Depression/psychology , Female , Follow-Up Studies , Geriatric Assessment , Germany/epidemiology , Humans , Incidence , Male , Memory Disorders/epidemiology , Memory Disorders/psychology , Mobility Limitation , Multivariate Analysis , Predictive Value of Tests , Proportional Hazards Models , Psychiatric Status Rating Scales , Risk Assessment , Risk Factors , Sex Factors , Smoking/epidemiology , Smoking/psychology , Time Factors , Vision Disorders/epidemiology , Vision Disorders/psychology
15.
Patient Educ Couns ; 93(1): 18-26, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23199592

ABSTRACT

OBJECTIVE: To develop learning objectives for a core communication curriculum for all health care professions and to survey the acceptability and suitability of the curriculum for undergraduate European health care education. METHODS: Learning objectives for a Health Professions Core Communication Curriculum (HPCCC) in undergraduate education were developed based on international literature and expert knowledge by an international group of communication experts representing different health care professions. A Delphi process technique was used to gather feedback and to provide a consensus from various health care disciplines within Europe. RESULTS: 121 communication experts from 15 professional fields and 16 European countries participated in the consensus process. The overall acceptance of the core communication curriculum was high. 61 core communication objectives were rated on a five-point scale and found to be relevant for undergraduate education in health care professions. A thematic analysis revealed the benefits of the HPCCC. CONCLUSIONS AND PRACTICE IMPLICATIONS: Based on a broad European expert consensus, the Health Professions Core Communication Curriculum can be used as a guide for teaching communication inter- and multi-professionally in undergraduate education in health care. It can serve for curriculum development and support the goals of the Bologna process.


Subject(s)
Communication , Curriculum , Education, Medical, Undergraduate/methods , Health Personnel/education , Clinical Competence , Consensus , Delphi Technique , Education, Medical, Undergraduate/organization & administration , Europe , Humans , Models, Educational , Physician-Patient Relations
16.
J Am Geriatr Soc ; 60(7): 1286-91, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22703453

ABSTRACT

OBJECTIVES: To examine the effect of cardiovascular and metabolic diseases on initial cognitive test performance and rate of change in three cognitive measures. DESIGN: Prospective cohort study. SETTING: General practices in six towns throughout Germany. PARTICIPANTS: Three thousand three hundred twenty-seven participants aged 75 and older (average 79.7 ± 3.6). MEASUREMENTS: Data were collected during home visits every 18 months and included sociodemographic variables, depression, disease status, drug intake, and cognition. RESULTS: Although the presence of transient ischemic attack (TIA) or stroke and diabetes mellitus was related to poor initial cognitive test performance, the presence of those and other far-reaching chronic diseases or a higher disease burden were not related to the rate of change in cognition over time. CONCLUSION: Diabetes mellitus, stroke and TIA affect cognitive test performance beyond well-known sociodemographic variables and depressive symptoms, although none of these diseases contributed to cognitive decline over time. In practical terms, prevention and diagnosis of cardiovascular and metabolic diseases may be essential to cognitively healthy aging.


Subject(s)
Cardiovascular Diseases/complications , Cardiovascular Diseases/physiopathology , Cognition Disorders/etiology , Cognition Disorders/physiopathology , Diabetes Mellitus/physiopathology , Aged , Aged, 80 and over , Depression/complications , Depression/physiopathology , Female , Germany , Humans , Interviews as Topic , Longitudinal Studies , Male , Prospective Studies , Psychiatric Status Rating Scales
17.
J Alzheimers Dis ; 25(3): 421-4, 2011.
Article in English | MEDLINE | ID: mdl-21422520

ABSTRACT

A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.


Subject(s)
Alzheimer Disease/blood , Alzheimer Disease/genetics , Clusterin/blood , Clusterin/genetics , Genetic Predisposition to Disease/genetics , Genetic Variation/genetics , Aged, 80 and over , Analysis of Variance , Enzyme-Linked Immunosorbent Assay , Female , Genome-Wide Association Study/methods , Humans , Longitudinal Studies , Male , Risk Factors
18.
Arch Gen Psychiatry ; 67(4): 414-22, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20368517

ABSTRACT

CONTEXT: Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD). OBJECTIVES: To determine the risk for conversion to any dementia, dementia in AD, or vascular dementia by SMI, graded by the level of SMI-related worry and by the temporal association of SMI and subsequent MCI. DESIGN: Longitudinal cohort study with follow-up examinations at 1(1/2) and 3 years after baseline. SETTING: Primary care medical record registry sample. PARTICIPANTS: A total of 2415 subjects without cognitive impairment 75 years or older in the German Study on Aging, Cognition and Dementia in Primary Care Patients. MAIN OUTCOME MEASURES: Conversion to any dementia, dementia in AD, or vascular dementia at follow-up 1 or follow-up 2 predicted by SMI with or without worry at baseline and at follow-up 2 predicted by different courses of SMI at baseline and MCI at follow-up 1. RESULTS: In the first analysis, SMI with worry at baseline was associated with greatest risk for conversion to any dementia (hazard ratio [HR], 3.53; 95% confidence interval [CI], 2.07-6.03) or dementia in AD (6.54; 2.82-15.20) at follow-up 1 or follow-up 2. The sensitivity was 69.0% and the specificity was 74.3% conversion to dementia in AD. In the second analysis, SMI at baseline and MCI at follow-up 1 were associated with greatest risk for conversion to any dementia (odds ratio [OR], 8.92; 95% CI, 3.69-21.60) or dementia in AD (19.33; 5.29-70.81) at follow-up 2. Furthermore, SMI at baseline and amnestic MCI at follow-up 1 increased the risk for conversion to any dementia (OR, 29.24; 95% CI, 8.75-97.78) or dementia in AD (60.28; 12.23-297.10), with a sensitivity of 66.7% and a specificity of 98.3% for conversion to dementia in AD. CONCLUSION: The prediction of dementia in AD by SMI with subsequent amnestic MCI supports the model of a consecutive 3-stage clinical manifestation of AD from SMI via MCI to dementia.


Subject(s)
Cognition Disorders/psychology , Dementia/psychology , Memory Disorders/psychology , Aged , Aged, 80 and over , Alzheimer Disease/diagnosis , Alzheimer Disease/psychology , Cognition Disorders/diagnosis , Dementia/diagnosis , Disease Progression , Female , Germany , Humans , Logistic Models , Longitudinal Studies , Male , Memory Disorders/diagnosis , Proportional Hazards Models , Psychiatric Status Rating Scales , Risk Factors
19.
GMS Z Med Ausbild ; 27(5): Doc75, 2010.
Article in English | MEDLINE | ID: mdl-21818220

ABSTRACT

The aim of this paper, written by the committee of educational research methodology of the "Society for Medical Education" of the German-speaking countries, will give recommendations for the review process of scientific papers in medical education. The recommendations are based on the results of a workshop in 2007 and on a survey among reviewers of the journal GMS Z Med Ausbild. It reflects on international standards and research in medical education in Germany. The paper describes reviewer's function concerning the journal of GMS Z Med Ausbild and specifies criteria for the review process with regard to the editors and reviewers; it also gives proposals for a feedback to the author. The catalogue of criteria for the reviewers is pictured in a checklist. The present recommendations shall help to increase the quality of the review process and to improve the national and international acceptance of the journal GMS Z Med Ausbild. Additionally, transparency of the review processes will support authors to submit a scientific article of high quality.

20.
Dement Geriatr Cogn Disord ; 28(4): 365-72, 2009.
Article in English | MEDLINE | ID: mdl-19887799

ABSTRACT

BACKGROUND: Individuals with mild cognitive impairment (MCI) are at high risk of developing dementia and are a target group for preventive interventions. Therefore, research aims at diagnosing MCI at an early stage with short, simple and easily administrable screening tests. Due to the fact that the Clock Drawing Test (CDT) is widely used to screen for dementia, it is questionable whether it is suited to screen for MCI. METHODS: 3,198 primary care patients aged 75+ were divided into two groups according to their cognitive status, assessed by comprehensive neuropsychological testing: individuals without MCI and individuals with MCI. The CDT scores, evaluated by the scoring system of Sunderland et al. [J Am Geriatr Soc 1989;37:725-729], of both groups were compared. Multivariate analyses were calculated and the sensitivity and specificity of the CDT to screen for MCI were reported. RESULTS: Significant differences were found for CDT results: MCI patients obtained worse results than cognitively unimpaired subjects. CDT has a significant impact on the diagnosis of MCI. However, sensitivity and specificity as well as receiver operating characteristic analyses are not adequate, meaning that the CDT could not be named as an exact screening tool. LIMITATIONS: Applying different CDT versions of administration and scoring could yield different results. CONCLUSIONS: CDT does not achieve the quality to screen individuals for MCI.


Subject(s)
Aging/psychology , Cognition Disorders/diagnosis , Cognition Disorders/psychology , Cognition/physiology , Dementia/diagnosis , Dementia/psychology , Neuropsychological Tests/standards , Aged , Aged, 80 and over , Alzheimer Disease/diagnosis , Alzheimer Disease/psychology , Dementia, Multi-Infarct/diagnosis , Dementia, Multi-Infarct/psychology , Executive Function/physiology , Female , Germany , Humans , Logistic Models , Longitudinal Studies , Male , Middle Aged , Patients , Primary Health Care , Prospective Studies , Psychiatric Status Rating Scales , Regression Analysis , Reproducibility of Results
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