Difficulty associated with donning medical compression stockings: results from a survey comparing two different compression stockings.

AIM: Although medical compression stockings (MCSs) represent the cornerstone of conservative treatment for patients with chronic venous disease, high rates of noncompliance exist. This study compared comfort levels and the difficulty associated with putting on/removing two different MCSs; a conventional degressive MCS (ankle pressure: 24-28 mmHg; calf pressure: 14-18 mmHg) and a progressive MCS (ankle pressure: 8-12 mmHg; calf pressure: 21-25 mmHg). PATIENTS & METHODS: Women wearing class III MCSs in the past 3 months were recruited from across France to complete an at-home, investigator-led questionnaire, designed to evaluate their experience with putting on/taking off MCSs. Patients were randomized to two groups (group 1: controls, degressive stocking right leg, then left leg; group 2: degressive stocking right leg, then progressive stocking left leg). RESULTS & CONCLUSION: Patients (n = 102) in group 1 (controls) reported no differences after wearing the degressive MCS on the right leg then the left leg. By contrast, group 2 patients (n = 118) reported statistically significant improvements with the progressive MCS compared with the degressive MCS in all questionnaire parameters, including 'comfort' and 'ease of putting on/taking off' dimensions. Progressive MCSs were associated with significantly better outcomes (ease of putting on/taking off and comfort) than the conventional MCSs.

Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study.

Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (-10.9 %, p = 0.026) and 3M (-10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (-8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance.