ABSTRACT
Iontophoresis is a process that uses electrical current to increase the flux of ionized substances through tissue. Iontophoresis has been used in rehabilitation to decrease inflammation and pain using dexamethasone and lidocaine. In 1993, Chang et al. reported visual improvements in the lesions of nine patients diagnosed with basal cell carcinoma (BCC) following iontophoresis of cisplatin. The present case report describes the successful treatment of a 67-year-old male with a histologically confirmed BCC on his upper anterolateral left leg. The treatment consisted of four cycles of five successive days of cisplatin iontophoresis, with a 2-week rest period between cycles. The cisplatin solution (5 mL at 1 mg/mL) was used in combination with epinephrine hydrochloride. The effectiveness of the treatment was confirmed by post-treatment biopsies, which revealed granulation tissue scarring without evidence of BCC. Measurements of cellular proliferation were monitored immunohistochemically with Ki-67 and cell cycle distribution analyzed by flow cytometry.
Subject(s)
Antineoplastic Agents, Alkylating/administration & dosage , Carcinoma, Basal Cell/drug therapy , Cisplatin/administration & dosage , Iontophoresis , Skin Neoplasms/drug therapy , Aged , Antineoplastic Agents, Alkylating/therapeutic use , Carcinoma, Basal Cell/chemistry , Carcinoma, Basal Cell/pathology , Cell Cycle , Cisplatin/therapeutic use , Drug Administration Schedule , Drug Evaluation , Epinephrine/administration & dosage , Flow Cytometry , Humans , Ki-67 Antigen/analysis , Leg , Male , Neoplasm Proteins/analysis , Skin Neoplasms/chemistry , Skin Neoplasms/pathologyABSTRACT
The cost and difficulty of obtaining cadavers to teach anatomy in allied health programs and in medical schools have led to the development of new interactive technology to complement cadaver dissection. However, the price of these computer software packages often limits the schools from purchasing these products. The advantages of the Internet in the academic setting (easy and global accessibility associated with low cost) enticed us to develop an Internet site to study the anatomy of the knee. This article describes the process of developing an Internet site, the procedure for accessing an Internet site, and the contribution of Internet sites to the teaching of anatomy to students. Finally, this article provides addresses on the Internet for other anatomy sites related to the anatomy of the knee. In conclusion, our Internet site allows the students to study anatomy at a low cost while utilizing a new and exciting educational medium.
