ABSTRACT
ABSTRACT: 68 Ga-FAPI has been introduced recently in many nuclear medicine centers. Many pitfalls have been discussed previously. However, not all pitfalls are currently addressed in the literature. To our knowledge, this is the first reported case to address nonspecific 68 Ga-FAPI expression at anorectal sphincter. A 69-year-old woman was diagnosed with intrahepatic cholangiocarcinoma. A 68 Ga-FAPI scan was performed after diagnostic workup and chemoradiotherapy. In addition to 68 Ga-FAPI-avid lesion at primary site, several nononcological ancillary findings have been observed. This includes unaddressed 68 Ga-FAPI-avid focus within anorectal sphincter. Moreover, the same noteworthy findings were observed in the musculoskeletal and gynecological systems.
Subject(s)
Bile Duct Neoplasms , Positron Emission Tomography Computed Tomography , Female , Humans , Aged , Bile Ducts, Intrahepatic , Fluorodeoxyglucose F18ABSTRACT
Colorectal cancer is a common malignancy, with the liver being the most frequent site of metastases. [18F] Fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) has emerged as a valuable tool in detecting and evaluating liver metastases and extrahepatic disease. Herein, we present a case of a 76-year-old male with colorectal cancer associated with lung and liver metastases. The patient received 12 chemoimmunotherapy cycles and was then put on maintenance cetuximab; serial [18F]FDG PET/CT scans were utilized to evaluate treatment response. The patient exhibited a positive response to chemoimmunotherapy, with regression of rectal disease and resolution of pulmonary metastatic nodules. Serial [18F]FDG PET/CT scans unveiled three distinct necrotic patterns. The case report advocates that [18F]FDG PET/CT plays an important role in evaluating colorectal liver metastases (CRLM) response to treatment, identifying transient necrosis, early recurrence, and emphasizing the limitations of post-treatment CT scans in identifying early CRLM recurrence. Integrating functional imaging, particularly [18F]FDG PET/CT, promises for management monitoring and surveillance of CRLM patients.
