ABSTRACT
This study was performed to investigate the biochemical effect of flaxseed oil on oxidative stress and brain monoamines release in streptozotocin-induced diabetic rats. Sixty male albino rats were divided into following four groups (15 for each group): control group, flaxseed oil group, diabetic group, and flaxseed oil-treated diabetic group. Serum glucose, insulin, pentosidine, plasma advanced oxidation protein products (AOPPs), and plasma total antioxidant capacity were estimated. Brain neurotransmitters, malondialdehyde (MDA), and nitric oxide (NO) were also determined. The mean values of serum pentosidine and plasma AOPP showed a significant decrease in treated diabetic group as compared to their values in the diabetic group. Also, brain neurotransmitters levels were improved after treatment with flaxseed. Brain MDA and NO were increased significantly in the diabetic group, while they were significantly decreased after treatment. Brain NO and brain MDA had a significant positive correlation with pentosidine, AOPP, and neurotransmitters. We concluded that flaxseed oil supplementation may be useful in the treatment of brain dysfunction in diabetes.
Subject(s)
Brain/drug effects , Diabetes Mellitus, Experimental/metabolism , Linseed Oil/pharmacology , Animals , Blood Glucose/analysis , Brain/metabolism , Diabetes Mellitus, Experimental/blood , Dietary Supplements , Dopamine/metabolism , Insulin/blood , Male , Malondialdehyde/metabolism , Nitric Oxide/metabolism , Norepinephrine/metabolism , Oxidative Stress/drug effects , Rats, Sprague-Dawley , Serotonin/metabolismABSTRACT
BACKGROUND: Pilonidal sinus (PNS) is chronic inflammatory process of the skin in the natal cleft. Management of PNS is mainly surgical. Although different types of surgery have been performed, the recurrence rate is still high. OBJECTIVE: To evaluate the effectiveness of laser hair removal (LHR) in the natal cleft area on the recurrence rate of PNS as an adjuvant therapy after surgical treatment. METHODS: Twenty five patients with PNS were included in this study. Fifteen patients underwent LHR treatment using Nd:YAG laser after surgical excision of PNS (Patients group) while ten subjects with PNS did not do LHR and served as a control group. RESULTS: All of the patients were male patients. Their age ranged from 17 to 29 years with a mean of 21.60 +/- 3.13 years. They had Fitzpatrick skin type III, IV and V. The patients have got 3 to 8 sessions of LHR (mean 4.87 +/- 1.64). Follow up period lasted between 12 to 23 months. None of the patients, who underwent LHR, has required further surgical treatment to date. Seven patients out of ten in the control group have developed recurrent PNS. Pain was the most frequent side effect and it was seen in 6 patients (40%). CONCLUSION: LHR can prevent the recurrence of PNS. LHR should be advised as an essential adjuvant treatment after surgical excision of PNS. In non-complicated recurrent PNS, LHR is strongly advocated to be started before and continued after doing surgical treatment.
Subject(s)
Hair Removal/methods , Lasers, Solid-State/therapeutic use , Pilonidal Sinus/surgery , Adolescent , Adult , Humans , Male , Secondary Prevention , Time Factors , Treatment Outcome , Wound Healing , Young AdultABSTRACT
Leishmania strain was isolated from a human case of cutaneous leishmaniasis and inoculated into experimental animals. Group of infected animals were given Dapsone, at a dose of 25 mg/kg for 3 weeks. Results showed that infected animals suffered from autoamputation of the inoculated foot pad. On the other hand, those receiving Dapsone showed complete clinical cure. Transmission Electron Microscope of both groups revealed the fine structure of Leishmania amastigotes. Those given Dapsone showed considerable reversible changes which didn't affect parasitic virulence. This latter has been demonstrated by their ability to infect experimental animals. leading to pathological lesion. It should be pointed out that patients treated with this drug and showed marked clinical response must be very carefully examined for fear of residual parasites which may be the cause of relapse later on.
