Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
J Med Life ; 8(1): 55-61, 2015.
Article in English | MEDLINE | ID: mdl-25914740

ABSTRACT

Multiple myeloma and JAK2 positive chronic myeloproliferative neoplasms are hematologic malignancies with a completely different cellular origin. Two cases of simultaneous occurrence of multiple myeloma, one with primary myelofibrosis and another one with essential thrombocythemia are reported in this article. In such cases, an accurate diagnosis requires a molecular testing, including gene sequencing and differential diagnosis of pancytosis associated with splenic amyloidosis. In general, in such cases, of two coexisting malignant hematologic diseases, the treatment of the most aggressive one is recommended. For our two cases, it was decided to start a Velcade based therapy. The main concern was the medullar toxicity, especially when a multiple myeloma was associated with a primary myelofibrosis.


Subject(s)
Janus Kinase 2/genetics , Multiple Myeloma/enzymology , Multiple Myeloma/genetics , Myeloproliferative Disorders/enzymology , Myeloproliferative Disorders/genetics , Aged , Biopsy , Bone Marrow/pathology , Cryoglobulins/metabolism , Female , Humans , Multiple Myeloma/pathology , Myeloproliferative Disorders/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...