1.
Bioorg Med Chem Lett
; 20(15): 4587-92, 2010 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-20594842
ABSTRACT
Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors' physiochemical and DMPK properties.