Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence.

The prevalence of diabetes has reached alarming levels in India, making it essential to understand the concentration of nutritional-trace elements (Fe, Cu, Zn, Cr. and Se) in blood samples from diabetic adults. In this study, 208 whole blood samples from diabetic (n = 104) and non-diabetic (n = 104) adults across various age groups were analyzed using total reflection X-ray fluorescence (TXRF) spectroscopy with a sample dilution method. Statistical analysis was performed to assess descriptive statistics and determine a significant correlation between elemental concentrations in the blood samples of diabetic and non-diabetic adults. The mean concentration of nutritional-related trace elements in diabetic blood was as follows: Fe (46 ± 5) > Zn (1.28 ± 0.14) > Cu (0.10 ± 0.01) > Cr (0.05 ± 0.004) > Se (0.013 ± 0.001) in mg/L, respectively. Additionally, this study investigated the influence of nutrition-related trace element concentrations across various age groups such as 25-40 years (young adults), 41-55 years (middle-aged adults), and 56-70 years (older adults). In this investigation, Zn (p < 0.001) and Cr (p < 0.05) concentrations differed significantly between diabetic and non-diabetic adults aged 56-70 years. These findings will help us to understand age-dependent changes in element concentrations, clarify their role in diabetes, and improve risk factor management associated with diabetes.

An experimental approach to determine the gamma radiation interaction mean free path and exposure buildup factor for biomolecules.

This experimental approach was designed to understand the gamma interaction parameters for the essential biomolecules, including starch soluble, cholesterol, myristic acid, glucose, oxalic acid, dextrose, salicylic acid, ethyl cellulose and sucrose. The empirical determination of gamma interaction parameters, such as interaction mean-free-path (MFP), buildup factor, and effective atomic number (Zeff) was performed by measuring mass attenuation coefficient (µ/ρ) at energies of 356 keV, 511 keV, 662 keV, 1173 keV, 1275 keV and 1332 keV. This was achieved using weak radioactive sources and a NaI(Tl) scintillation spectrometer with collimated and non-collimated transmission geometry. The experimentally determined values of gamma-ray interaction parameters were obtained non-destructively and precisely agreeing with the expected values from simulations and codes. In addition, the research findings also revealed a novel trend in gamma interaction mean free path as a function of energy and variable buildup factors for the selected biomolecules. These research findings provide valuable insight into the process of gamma radiation interaction. This approach may fulfil the increasing demand of medical, technical and academic research laboratories for a cost-effective and reliable empirical methodology to understand gamma radiation interaction with matter.

Investigation of the nuclear radiation interaction parameters of selected polymers for radiation therapy and dosimetry.

The mass attenuation coefficient (MAC), effective atomic number (Zeff), equivalent atomic number (Zeq), fast neutron removal cross-section (FNRCS), energy absorption buildup factor (EABF), mass-energy absorption coefficient (MenAC), relative kerma, and computed tomography (CT) numbers were calculated for the alginates, bisphenol A-glycidyl methacrylate (Bis-GMA), chitin, hyaluronic acid, polycaprolactone (PCL), polyether ether ketone (PEEK), polyethylene glycol (PEG), polyglycolide (PGA), polylactic acid (PLA), poly lacto-co-glycolic acid (PLGA), poly methyl methacrylate (PMMA), poly vinyl alcohol (PVA), polyvinylpyrrolidone (PVP), triethylene glycol dimethacrylate (TEGDMA), and urethane dimethacrylate (UDMA) polymers using the Phy-X/PSD and Py-MLBUF software. The total stopping power (TSP) of electrons, protons, and alpha particles was calculated for the selected polymers using the ESTAR, PSTAR, and ASTAR programs. The effective atomic number for absorption and charged particle (electron, proton, alpha, and carbon ion) interactions were estimated for the selected polymers using Phy-X/ZeXTRa software. The FNRCS values of Bis-GMA, PCL, PEG, PMMA, and PVP were similar to those of the human tissues. For the selected polymers, the Zeff values for electron, proton, alpha, and carbon ion interactions of PCL, PEG, PLGA, and PVA were similar to those of human tissues, except for the cortical bone, across the entire energy range. These results are expected to assist in selecting suitable polymers as tissue-equivalent materials in the desired energy range for photon, neutron, and charged-particle interactions. This study is expected to be useful for radiation therapy and dosimetry.

Investigation of gamma-ray shielding parameters of bismuth phospho-tellurite glasses doped with varying Sm2O3.

The gamma ray shielding parameters such as mass attenuation coefficient, effective atomic number, equivalent atomic number, exposure buildup factor, and energy absorption buildup factor were determined for the 47.5P2O5+45ZnO+(5-x) Bi2O3+2.5TeO2 +xSm2O3 glass system using Phy-X/PSD software in the energy range from 0.015 to 15 MeV at penetration depths of 1-40 MFP. To understand the effect of Sm2O3 on gamma ray shielding parameters in selected glass system, the Sm2O3 was varied in the glass from 0.01 to 1 mol%. The calculated results show that the mass attenuation coefficient decreases with increasing photon energy but not influenced by the addition of Sm2O3. The Zeq values are lower in low (≤100 keV) and high energy regions (1 MeV-15 MeV) and higher in the medium energy region, indicating that the Compton scattering is significant in the medium energy region. The values of exposure buildup factors and energy absorption buildup factors are smaller in the low and high energy regions than in the intermediate energy region, indicating that the photo absorption and pair creation processes are important in the low and high energy regions, respectively. The 1% mole concentration of Sm2O3 in the selected glass shows higher exposure buildup factor and energy absorption buildup factor values in the intermediate energy region. The high density, high effective atomic number, and transparency to visible light of these materials indicate that they can be used as shielding materials in nuclear reactors and nuclear technology.

Neutron kerma factors and water equivalence of some tissue substitutes.

The Kerma factors and Kerma relative to the air and water of 24 compounds that are used as tissue substitutes were calculated for neutron energies ranging from 2.53×10(-8) to 29 MeV. The Kerma ratios of the tissue substitutes relative to air and water were calculated. The water equivalence of the selected tissue substitutes was observed above neutron energies of 100 eV. The Kerma ratio relative to the air for poly-vinylidene fluoride and Teflon were nearest to unity at very low energy (up to 1 eV) and above 63 eV, respectively. It was found that the natural rubber was a water-equivalent tissue substitute compound. The results of the Kerma factors in our investigation show good agreement with those published in ICRU-44. We found that at higher neutron energies, the Kerma factors and Kerma ratios of the selected tissue substitute compounds were approximately the same, but though the differences were large for energies below 100 eV.

Effective atomic numbers of some tissue substitutes by different methods: A comparative study.

Effective atomic numbers of some human organ tissue substitutes such as polyethylene terephthalate, red articulation wax, paraffin 1, paraffin 2, bolus, pitch, polyphenylene sulfide, polysulfone, polyvinylchloride, and modeling clay have been calculated by four different methods like Auto-Zeff, direct, interpolation, and power law. It was found that the effective atomic numbers computed by Auto-Zeff, direct and interpolation methods were in good agreement for intermediate energy region (0.1 MeV < E < 5 MeV) where the Compton interaction dominates. A large difference in effective atomic numbers by direct method and Auto-Zeff was observed in photo-electric and pair-production regions. Effective atomic numbers computed by power law were found to be close to direct method in photo-electric absorption region. The Auto-Zeff, direct and interpolation methods were found to be in good agreement for computation of effective atomic numbers in intermediate energy region (100 keV < E < 10 MeV). The direct method was found to be appropriate method for computation of effective atomic numbers in photo-electric region (10 keV < E < 100 keV). The tissue equivalence of the tissue substitutes is possible to represent by any method for computation of effective atomic number mentioned in the present study. An accurate estimation of Rayleigh scattering is required to eliminate effect of molecular, chemical, or crystalline environment of the atom for estimation of gamma interaction parameters.

The gamma-ray and neutron shielding factors of fly-ash brick materials.

A comprehensive study of gamma-ray exposure build-up factors (EBFs) of fly-ash brick materials has been carried out for photon energies of 0.015-15 MeV up to a penetration depth of 40 mfp (mean free path) by a geometrical progression (GP) fitting method. The EBF values of the fly-ash brick materials were found to be dependent upon the photon energy, penetration depth and chemical composition, and were found to be higher than the values for mud bricks and common bricks. Above a photon energy of 3 MeV for large penetration depths (>10 mfp), the EBF becomes directly proportional to Zeq. EBFs of fly-ashes were found to be less than or equal to those of concrete for low penetration depths (<10 mfp) for intermediate photon energies up to 1.5 MeV. The EBF values of fly-ash materials were found to be almost independent of Si concentration. The fast neutron removal cross sections of the fly-ash brick materials, mud bricks and common bricks were also calculated to understand their shielding effectiveness. The shielding effectiveness of the fly-ash materials against gamma-ray radiation was lower than that of common and mud bricks.

Measurement of real and imaginary form factors of silver atom using a high resolution HPGe detector.

The real and imaginary form factors of silver atom have been determined by using EDXRF method. The K x-ray photons in the energy range from 8.62 keV to 52.18 keV are generated by sending 59.56 keV gamma photons from ^{241}Am radioactive source on various targets. These K x-ray photons are transmitted through silver foils of suitable thickness. The incident and transmitted K x-ray photon intensities have been measured with a high resolution HPGe detector which is coupled to 16K MCA. The photoelectric cross sections at different K x-ray energies have been determined by measuring the intensities of the incident and transmitted x-ray photons. From these photoelectric cross section values, the imaginary form factors and the real form factors have been determined at various photon energies. Measured imaginary and real form factor values have been compared with theoretical values predicted by XCOM [23] and FFAST [24].

Quick management of accidental tritium exposure cases.

Removal half-life (RHL) of tritium is one of the best means for optimising medical treatment, reduction of committed effective dose (CED) and quick/easy handling of a large group of workers for medical treatment reference. The removal of tritium from the body depends on age, temperature, relative humidity and daily rainfall; so tritium removal rate, its follow-up and proper data analysis and recording are the best techniques for management of accidental acute tritium exposed cases. The decision of referring for medical treatment or medical intervention (MI) would be based on workers' tritium RHL history taken from their bodies at the facilities. The workers with tritium intake up to 1 ALI shall not be considered for medical treatment as it is a derived limit of annual total effective dose. The short-term MI may be considered for tritium intake of 1-10 ALI; however, if the results show intake ≥100 ALI, extended strong medical/therapeutic intervention may be recommended based on the severity of exposure for maximum CED reduction requirements and annual total effective dose limit. The methodology is very useful for pressurized heavy water reactors (PHWRs) which are mainly operated by Canada and India and future fusion reactor technologies. Proper management will optimise the cases for medical treatment and enhance public acceptance of nuclear fission and fusion reactor technologies.

Estimation of biological half-life of tritium in coastal region of India.

The present study estimates biological half-life (BHL) of tritium by analysing routine bioassay samples of radiation workers. During 2007-2009 year, 72,100 urine bioassay samples of the workers were analysed by liquid scintillation counting technique for internal dose monitoring for tritium. Two hundred and two subjects were taken for study with minimum 3 µCiL(-1) tritium uptake in their body fluid. The BHL of tritium of subjects ranges from 1 to 16 d with an average of 8.19 d. Human data indicate that the biological retention time ranges from 4 to 18 d with an average of 10 d. The seasonal variations of the BHL of tritium are 3.09 ± 1.48, 6.87 ± 0.58 and 5.73 ± 0.76 d (mean ± SD) for summer, winter and rainy seasons, respectively, for free water tritium in the coastal region of Karnataka, India, which shows that the BHL in summer is twice that of the winter season. Also three subjects showed the BHL of 101.73-121.09 d, which reveals that organically bound tritium is present with low tritium uptake also. The BHL of tritium for all age group of workers is observed independent of age and is shorter during April to May. The distribution of cumulative probability vs. BHL of tritium shows lognormal distribution with a geometric mean of 9.11 d and geometric standard deviation of 1.77 d. The study of the subjects is fit for two-compartment model and also an average BHL of tritium is found similar to earlier studies.