Subject(s)
Congresses as Topic , Gastroenterology/organization & administration , Africa, Northern , Communication , Congresses as Topic/standards , Gastroenterology/methods , Gastroenterology/standards , Gastroenterology/trends , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/therapy , Humans , Societies, Medical/organization & administration , Societies, Medical/standards , Societies, Medical/trends , TunisiaABSTRACT
The purpose of this study was to investigate whether common variants in inflammatory and immune response genes influence inflammatory bowel disease (IBD) risk among Moroccan patients. Using a candidate gene approach, 10 single-nucleotide polymorphisms mapping on six genes (MIF_rs755622, TNFA_rs1800629, IL6_rs2069840, IL6R_rs2228145, IL6ST_rs2228044, IL17A (rs2275913, rs4711998, rs7747909, rs8193036, rs3819024)) were assessed in 510 subjects grouped in 199 IBD and 311 healthy controls. Genotyping was performed with the TaqMan allelic discrimination technology. The results were analyzed using PLINK software. The frequency of allele A for TNFA rs1800629 was significantly higher in ulcerative colitis (UC) patients compared with controls (30.16 vs 16.72%; P=0.0005; odds ratio (OR)=2.15; 95% confidence interval (CI)=1.39-3.32). Statistically significant association to UC was also found under dominant AA+AG vs GG (OR=1.85, 95% CI=1.07-3.21; P=0.02) and recessive models (OR=8.38; 95% CI=2.86-24.53; P=0.0001). In the same way, an association of TNFA rs1800629 variant was observed with IBD under recessive model AA vs AG+GG (OR=4.10; 95% CI=1.56-10.76; P=0.004). No evidence of significant associations was found for the remaining investigated polymorphisms. Our data suggest that TNFA gene promoter polymorphism participates in determining IBD susceptibility in Moroccan patients.
Subject(s)
Colitis, Ulcerative/genetics , Inflammatory Bowel Diseases/genetics , Polymorphism, Single Nucleotide , Tumor Necrosis Factor-alpha/genetics , Adolescent , Adult , Aged , Colitis, Ulcerative/immunology , Crohn Disease/genetics , Cytokines/genetics , Cytokines/immunology , Female , Humans , Inflammatory Bowel Diseases/immunology , Male , Middle Aged , Morocco , Receptors, Cytokine/genetics , Receptors, Cytokine/immunology , Tumor Necrosis Factor-alpha/immunology , Young AdultABSTRACT
INTRODUCTION: Colorectal cancer is a major public health problem. However, this cancer is usually developed on preexisting lesion. This makes this cancer accessible to a prevention strategy. OBJECTIVE: The aim of this study was to determine the clinicopathologic characteristics of patients under 50 years. PATIENTS AND METHODS: This study involved 133 patients with colorectal cancer recruited in CHU Ibn-Rochd, Casablanca. Data relating age, sex, stage at presentation, histological type and tumor location were obtained from the pathological and clinical records of each patient. Statistical analysis was performed to compare clinicopathological data in patients under 50 years and in older patients. RESULTS AND DISCUSSION: The average age of patients was 54 years. The frequency of patients aged 50 or under was 40.6% The tumors in the youngest age group were more often mucinous and signet ring cells (18.5%) versus (5.1%) in the oldest age group. The right colon was more often affected in the youngest age group, 38.9% versus 17.7% in the oldest age group (P=0.008). CONCLUSION: The proposition of colorectal cancer in subjects 50 or under was high in Morocco. Colorectal cancers in the youngest age group were more often mucinous or signet ring cells and was more often located in the right colon. We intend to complete this study by a genetic study to help improve prevention and care of young patient.
Subject(s)
Adenocarcinoma/epidemiology , Adenocarcinoma/pathology , Colorectal Neoplasms/epidemiology , Colorectal Neoplasms/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Cell Differentiation , Female , Humans , Male , Middle Aged , Morocco/epidemiology , Neoplasm Staging , Young AdultABSTRACT
The authors report a retrospective study of 27 cases of "ileo-caecal tuberculosis" collected over a period of 10-years. Sixteen women and eleven men, between 14 and 55 years of age (with a group mean age of 28 years), were included. This is still a common disease in Morocco, despite attempts to achieve universal BCG vaccination. Diarrhoea, abdominal pain and a general physical deterioration are the most indicative signs, but are not specific. Tests for M. tuberculosis hominis are often negative, except in cases in which bacteria proliferate in pulmonary excavations, and this makes it difficult to establish a definite diagnosis. The detection of narrowing of the ileum or colon in a country where infection is endemic suggests the possibility of tuberculosis. Colonoscopy, which is becoming increasingly widespread in Morocco, makes an essential contribution. Although it is rare for caseum to be detected in biopsy fragments, the main value of histopathology is that it can eliminate cancer, making it possible to start antibacterial treatment without a diagnostic laparotomy. The outcome of medical treatment is nearly always positive. Clinical improvement, bacteriology tests and X-ray examinations are criteria that a cure has been obtained.
