Prognostic factors for the development of upper limb dysfunctions after breast cancer: the UPLIFT-BC prospective longitudinal cohort study protocol.

INTRODUCTION: Upper limb (UL) dysfunctions are highly prevalent in people after breast cancer and have a great impact on performing activities in daily living. To improve care, a more comprehensive understanding of the development and persistence of UL dysfunctions is needed. Therefore, the UPLIFT-BC study will primarily examine the prognostic value of different factors at the body functions and structures, environmental and personal level of the International Classification of Functioning, Disability and Health (ICF) framework at 1-month post-surgery for persisting UL dysfunctions at 6 months after finishing cancer treatment. METHODS AND ANALYSIS: A prospective longitudinal cohort study, running from 1-week pre-surgery to 6 months post-local cancer treatment, is performed in a cohort of 250 women diagnosed with primary breast cancer. Different potentially prognostic factors to UL dysfunctions, covering body functions and structures, environmental and personal factors of the ICF, are assessed pre-surgically and at different time points post-surgery. The primary aim is to investigate the prognostic value of these factors at 1-month post-surgery for subjective UL function (ie, QuickDASH) at 6 months post-cancer treatment, that is, 6 months post-radiotherapy or post-surgery (T3), depending on the individuals' cancer treatment trajectory. In this, factors with relevant prognostic value pre-surgery are considered as well. Similar analyses are performed with an objective measure for UL function (ie, accelerometry) and a composite score of the combination of subjective and objective UL function. Second, in the subgroup of participants who receive radiotherapy, the prognostic value of the same factors is explored at 1-month post-radiotherapy and 6 months post-surgery. A forward stepwise selection strategy is used to obtain these multivariable prognostic models. ETHICS AND DISSEMINATION: The study protocol was approved by the Ethics Committee of UZ/KU Leuven (reference number s66248). The results of this study will be published in peer-reviewed journals and will be presented at several research conferences. TRIAL REGISTRATION NUMBER: NCT05297591.

Reliability of 3D Lower Extremity Movement Analysis by Means of Inertial Sensor Technology during Transitional Tasks.

This study assesses the reliability and agreement of trunk and lower limb joints' 3D kinematics, measured by inertial measurement units, during walking and more demanding movement tasks. For data analysis, tasks were divided in open and closed chain phases. Twenty healthy participants were included. On day one, measurements were conducted by "Operator 1" and "Operator 2" to determine between-operator reliability/agreement. On day two, the measurements were conducted by Operator 1, in order to determine within-session reliability/agreement. Furthermore, between-session reliability/agreement was assessed based on data from Operator 1, captured on day one and two. Within-session reliability/agreement was high, and better than between-session and between-operator results for all tasks. The results for walking were generally better than for other movement tasks, for all joint kinematics, and for both open and closed chain phases. Only for the ab/adduction and flexion/extension angles during forward and sideward lunge, reliability and agreement results were comparable to walking, for both the open and closed chain phases. The fact that lunges show similar reliability results than walking for open and closed chain phases, but require more motor control to perform, indicates that the performance of lunges might be interesting to use in further research aiming to identify kinematic differences between populations.