ABSTRACT
The article discusses various pathophysiological conditions and processes that lead to the development of tumors in diabetes mellitus. These include obesity, hyperglycemia, hyperinsulinemia, inflammation, and oxidative stress. The data of epidemiological studies are given, in which it was found that diabetes mellitus (both type 1 and type 2) increases the risk of developing the female reproductive system tumors, such as ovarian cancer, endometrial cancer, while for cervical cancer, vaginal cancer and vulvar cancer, such a relationship has not been clearly identified.
Subject(s)
Diabetes Mellitus , Genital Neoplasms, Female , Ovarian Neoplasms , Uterine Cervical Neoplasms , Female , Humans , Genital Neoplasms, Female/complications , Genital Neoplasms, Female/epidemiology , Genitalia, FemaleABSTRACT
Searches for the lepton number violating K^{+}âπ^{-}µ^{+}e^{+} decay and the lepton flavor violating K^{+}âπ^{+}µ^{-}e^{+} and π^{0}âµ^{-}e^{+} decays are reported using data collected by the NA62 experiment at CERN in 2017-2018. No evidence for these decays is found and upper limits of the branching ratios are obtained at 90% confidence level: B(K^{+}âπ^{-}µ^{+}e^{+})<4.2×10^{-11}, B(K^{+}âπ^{+}µ^{-}e^{+})<6.6×10^{-11} and B(π^{0}âµ^{-}e^{+})<3.2×10^{-10}. These results improve by 1 order of magnitude over previous results for these decay modes.
ABSTRACT
A multifactorial morphologic study was performed in 72 children (49 boys and 23 girls) aged from 2 to 16 years, operated on because of osteoid osteoma and osteoblastoma of 12 anatomical sites. It is shown that different variants of early stages of osteogenic tumours correspond to different levels of cell differentiation and atypia. The smallest foci of dysplasia found near the tumour should be considered as pretumorous bone dysplasia.
Subject(s)
Bone Neoplasms/pathology , Osteoblastoma/pathology , Adolescent , Bone and Bones/pathology , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Male , Osteoma, Osteoid/pathology , Time FactorsSubject(s)
Osteomyelitis , Anti-Bacterial Agents/therapeutic use , Child , Child, Preschool , Chronic Disease , Female , Follow-Up Studies , Humans , Male , Osteomyelitis/diagnosis , Osteomyelitis/therapy , Recurrence , Time FactorsSubject(s)
Bone Neoplasms/pathology , Foot Diseases/pathology , Osteoma, Osteoid/pathology , Adolescent , Amputation, Surgical , Bone Neoplasms/diagnosis , Bone Neoplasms/surgery , Foot/pathology , Foot/surgery , Foot Diseases/diagnosis , Foot Diseases/surgery , Humans , Male , Osteoma, Osteoid/diagnosis , Osteoma, Osteoid/surgery , Retrospective StudiesSubject(s)
Bone Neoplasms/diagnostic imaging , Fibroma/diagnostic imaging , Angiography , Bone Neoplasms/surgery , Bone and Bones/diagnostic imaging , Child , Child, Preschool , Female , Fibroma/surgery , Humans , Infant , Male , Neoplasm Recurrence, Local/diagnostic imaging , Neoplasm Recurrence, Local/surgery , ReoperationSubject(s)
Giant Cell Tumors/pathology , Osteoma, Osteoid/pathology , Adolescent , Child , Female , Humans , Male , Retrospective StudiesABSTRACT
Preoperative diagnosis of thyroid pathology was improved following a cytological examination of punctates from nodulated formations of the thyroid in patients living in goiter-endemic regions. Diagnosis of thyroid cancer was confirmed preoperatively in 78% of cases, which, in turn, warranted application of adequate surgical procedures.
Subject(s)
Disease Reservoirs , Goiter, Endemic/diagnosis , Thyroid Neoplasms/diagnosis , Cytodiagnosis , Diagnosis, Differential , Goiter, Endemic/pathology , Humans , Neoplasm Staging , Russia , Thyroid Gland/pathology , Thyroid Neoplasms/pathologySubject(s)
Carcinoid Tumor/pathology , Laryngeal Neoplasms/pathology , Adult , Humans , Male , Neoplasm StagingSubject(s)
Adenocarcinoma/diagnosis , Lung Neoplasms/diagnosis , Adult , Aged , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Pneumonia/diagnosisSubject(s)
Arterial Occlusive Diseases/etiology , Calcinosis/etiology , Fingers , Polycystic Kidney Diseases/complications , Toes , Arterial Occlusive Diseases/pathology , Calcinosis/pathology , Chronic Disease , Female , Humans , Middle Aged , Necrosis , Polycystic Kidney Diseases/pathology , Uremia/complications , Uremia/pathologySubject(s)
Fibroma , Lung Neoplasms , Adult , Fibroma/diagnostic imaging , Humans , Lung Neoplasms/diagnostic imaging , Male , RadiographyABSTRACT
A study was made of immunogenic properties of the cell wall and other cellular components of brucellae obtained by mechanical disntegration of bacteria. The greatest immunogenic properties proved to be possessed by the cell walls. In using the vaccine consisting o the living vaccine of the Br. abortus strain 19 and the cell walls of brucellae the efficacy of the preparation was not reduced in experiments on guinea pigs and mice.
