ABSTRACT
We examined 50 patients with acute myocardial infarction (MI) who in dependence on prescription in the content of basic therapy of sulfhydric group containing angiotensin converting enzyme inhibitors (ACEI) zofenopril and captopril were divided into 2 groups each comprizing 25 patients. We studied dynamics of lipid peroxidation, protective antioxidant systems, the state of endothelial function, systemic inflammation, and endogenous cytoprotective mechanisms - the system of nitric oxide (NO) and stress proteins of HSP70 family - during fist 24 hours of hospitalization, in 1 and 6 months after development of MI. We have found that long-term administration of ACEI promotes lowering of free radical oxidation products what is related to activation of protective antioxidant enzymes and total antioxidant activity of blood serum. Preparations also exert positive effect on the state of protective HSP70 system and parameters of endothelial function.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Endothelium, Vascular/physiopathology , Myocardial Infarction/blood , Oxidative Stress/drug effects , Adult , Aged , Aged, 80 and over , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Dose-Response Relationship, Drug , Endothelium, Vascular/drug effects , Female , Follow-Up Studies , Glutathione Peroxidase/blood , Humans , Male , Middle Aged , Myocardial Infarction/drug therapy , Myocardial Infarction/physiopathology , Spectrophotometry , Superoxide Dismutase/blood , Time Factors , Treatment OutcomeABSTRACT
Study of the efficacy of a course of exposures to travelling pulsed magnetic field and magnetic laser sessions in 97 patients with stages I-II essential hypertension showed a high efficacy of travelling pulsed magnetic field in patients with hyperkinetic hemodynamics and initially just slightly shifted blood rheology and platelet hemostasis. Magnetic laser therapy is more effective in patients with eukinetic and hypokinetic hemodynamics and initially sharply expressed disorders of blood rheology and platelet hemostasis.
Subject(s)
Hypertension/rehabilitation , Laser Therapy , Magnetics/therapeutic use , Adult , Aged , Combined Modality Therapy , Evaluation Studies as Topic , Female , Hemodynamics , Hemorheology , Humans , Hypertension/blood , Hypertension/physiopathology , Male , Middle Aged , PrognosisABSTRACT
158 patients with essential hypertension received beta-adrenoblockers and were exposed to travelling impulse magnetic field, magnetolaser radiation. The study of platelet-vessel hemostasis and blood rheology revealed a relation of good clinical response and increased exercise tolerance with initial platelet dysfunction and rheological disorders which underwent positive changes in the course of treatment.
Subject(s)
Blood Platelet Disorders/therapy , Hemorheology , Hemostasis , Hypertension/therapy , Adrenergic beta-Antagonists/administration & dosage , Adult , Aged , Antihypertensive Agents/administration & dosage , Atenolol/administration & dosage , Blood Platelet Disorders/blood , Blood Platelet Disorders/etiology , Blood Platelet Disorders/physiopathology , Combined Modality Therapy , Female , Hemorheology/drug effects , Hemorheology/radiation effects , Hemostasis/drug effects , Hemostasis/radiation effects , Humans , Hypertension/blood , Hypertension/etiology , Hypertension/physiopathology , Infrared Rays/therapeutic use , Laser Therapy , Magnetics/therapeutic use , Male , Middle AgedABSTRACT
A total of 80 patients aged 34 to 65 years who suffered from stage-II hypertensive disease were followed up. The selective beta-adrenoblocker tenolol was used alone. Platelet hemostasis, cyclic nucleotides, thromboxane-prostacyclin system and blood rheological properties were examined. Tenolol was found to have a pronounced antihypertensive effect in the patients and to be beneficial in correcting impaired blood rheological properties and platelet homeostasis. It is concluded that the baseline blood rheological properties and the status of the hemostatic system largely determine the natural history of hypertension and the efficacy of therapy.
