ABSTRACT
The epidemiological and clinical characteristics of cervical carcinoma in Sardinia were examined, with particular regard to the low incidence (6.47/100,000 women) of these neoplasias. Postsurgical adjuvant Radiotherapy in the high-risk cases has allowed a constant improvement in therapeutic results, with a low relapse-incidence and a high percentage of survival, especially in first and second stage treated cases.
Subject(s)
Uterine Cervical Neoplasms/therapy , Adenocarcinoma/epidemiology , Adenocarcinoma/mortality , Adenocarcinoma/pathology , Adenocarcinoma/secondary , Adenocarcinoma/therapy , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Incidence , Italy/epidemiology , Lymphatic Metastasis , Neoplasm Recurrence, Local , Neoplasm Staging , Survival Rate , Uterine Cervical Neoplasms/epidemiology , Uterine Cervical Neoplasms/mortality , Uterine Cervical Neoplasms/pathologyABSTRACT
We have considered 91 cases of uterine cervical carcinoma observed in the period 1980-89, of which 31 (34%) at stage 0, and 23 (25.2%) at stage IB. The operative index was of 85.7%. Of 78 cases operated, 22 (28.2%) were treated with post-surgical adjuvant radiotherapy because of the presence of risk factors. The relapse incidence (follow-up 8-118 months) was in total 14.6% (12 relapses) with an NED-survival of 79.1% (at the first stage B 4.3% of relapses with an NED-survival of 95.6%). We have emphasized the importance of adjuvant radiotherapy which has allowed the progressive improvement in the therapeutic results of the last years.
Subject(s)
Uterine Cervical Neoplasms/therapy , Adult , Aged , Aged, 80 and over , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Italy , Lymphatic Metastasis , Middle Aged , Neoplasm Recurrence, Local , Neoplasm Staging , Risk Factors , Survival Rate , Uterine Cervical Neoplasms/mortality , Uterine Cervical Neoplasms/pathologyABSTRACT
Malignant lymphomas concern the female genital tract in 30% of cases. The majority (more than 90%) are non-Hodgkin lymphoma, involving in order of frequency, ovary (49%), uterus (29%), Fallopian tubes (11%), vagina (7%), vulva (4%). So a primary vulvar localization seems to be quite unusual; in fact only 5 cases have been reported since 1937 up to now. We report a case of vulvar non-Hodgkin lymphoma we observed in our Institute.
Subject(s)
Lymphoma, Non-Hodgkin/diagnosis , Vulvar Neoplasms/diagnosis , Brain Neoplasms/secondary , Drug Therapy, Combination , Female , Humans , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/pathology , Lymphoma, Non-Hodgkin/surgery , Middle Aged , Prednisone/therapeutic use , Procarbazine/therapeutic use , Vinblastine/therapeutic use , Vulvar Neoplasms/drug therapy , Vulvar Neoplasms/surgeryABSTRACT
The Authors evaluated 87 cases of endometrial carcinoma, of whom 65 (74.7%) at pathological stage I. The surgical ratio was (96.5% 84/87 cases), and 31 cases were subjected to adjuvant postsurgical Radiotherapy because of the presence of risk factors. The incidence of relapses resulted complessively in 14.2%, with a NED-survival of 86.1% and an overall survival of 91.9% at the pathological stage I. The Authors emphasise particularly the importance of post-surgical Radiotherapy in the cases at risk, which allowed an important decrease of the incidence of relapses at stage I with regard to previous studies.
Subject(s)
Uterine Neoplasms/surgery , Aged , Female , Follow-Up Studies , Humans , Middle Aged , Neoplasm Staging , Recurrence , Retrospective Studies , Uterine Neoplasms/drug therapy , Uterine Neoplasms/pathology , Uterine Neoplasms/radiotherapyABSTRACT
In a retrospective study we examined 42 radical hysterectomies according to Wertheim-Meigs in the ten year period 1980-89, of whom 39 for carcinoma of the cervix, two for endometrial carcinoma at stage II one for microinvasive vaginal carcinoma. The incidence of relapses was 11.9% (5 cases) globally, with 3.7% at pathologic stage I, while the actuarial survival was 95.4% at stage I. The intraoperative, perioperative and postactinic complications related to integrated treatment are described, underlining the importance of post-surgical Radiotherapy in cases at risk.
Subject(s)
Uterine Cervical Neoplasms/surgery , Uterine Neoplasms/surgery , Vaginal Neoplasms/surgery , Female , Follow-Up Studies , Hospitals, Special , Humans , Hysterectomy/methods , Italy , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Postoperative Complications , Recurrence , Retrospective Studies , Uterine Cervical Neoplasms/pathology , Uterine Neoplasms/pathology , Vaginal Neoplasms/pathologyABSTRACT
The first line polichemotherapeutic regimens are compared (intracavitary Cyclophosphamide + CMF, ACy and PEC) in 47 patients with advanced ovarian carcinoma. The response was 56.4% for Ex-CMF (CR 39.1%), 76.8% for ACy (CR 61.5%) and 81.8% for PEC (CR 63.6%). The three-year survival was 39.1% with Ex-CMF, 53.8% with ACy and 72.7% (follow-up not yet completed) for PEC. Toxicity was modest in all the three therapeutic regimens.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Ovarian Neoplasms/drug therapy , Adult , Aged , Aged, 80 and over , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Cisplatin/administration & dosage , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Epirubicin/administration & dosage , Female , Fluorouracil/administration & dosage , Humans , Methotrexate/administration & dosage , Middle Aged , Neoplasm Staging , Ovarian Neoplasms/mortality , Survival RateABSTRACT
The biological and clinical characteristics of endometrial carcinoma in Sardinia were examined, with particular regard to the very high incidence (42.7/100,000 age-selected women) of this neoplasia in this Island. The use of post-surgical Radiotherapy on the basis of the protocols of integrated therapies allowed us to reduce the incidence of relapses in these last few years, with an evident increase in survival.
Subject(s)
Uterine Neoplasms/epidemiology , Adult , Aged , Female , Humans , Incidence , Italy/epidemiology , Middle Aged , Prognosis , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Uterine Neoplasms/metabolism , Uterine Neoplasms/therapyABSTRACT
The authors consider a rare case of non-Hodgkin primitive lymphoma of the vagina, 1st E stage for Ann Arbor classification. The treatment was primarily chemotherapy, because of the wide extension of the neoplasia and the older patient age, and it was followed by a complete clinical response, still lasting after two years. The results of treatments in the literature are at least examined and discussed.
