1.
Forensic Sci Int
; 13(2): 133-5, 1979.
Article
in English
| MEDLINE
| ID: mdl-447145
2.
Forensic Sci
; 8(3): 265-7, 1976.
Article
in English
| MEDLINE
| ID: mdl-1002076
3.
J Assoc Off Anal Chem
; 58(5): 875-8, 1975 Sep.
Article
in English
| MEDLINE
| ID: mdl-1158829
ABSTRACT
A colorimetric method is presented for the estimation of diazepam as the pure drug and in formulations. Diazepam is hydrolyzed with 6N HCl to 2-methylamino-5-chlorobenzophenone, which is extracted with chloroform to give a yellow solution whose absorbance is measured at 410 nm against a solvent blank. The color obeys Beer's law in the concentration range of 0-30 mug/ml. In 5 determinations, recovery was 99.0 +/- 1.9%. The method is applicable to pure diazepam and its formulations for oral and parenteral use. No interferences were observed from pyridoxine hydrochloride and commonly used preservatives, vehicles, and colors.
Subject(s)
Colorimetry/methods , Diazepam/analysis , Diazepam/standards , Dosage Forms , Infusions, Parenteral , Solutions/analysis , Spectrophotometry , Tablets
4.
J Assoc Off Anal Chem
; 57(5): 1144-6, 1974 Sep.
Article
in English
| MEDLINE
| ID: mdl-4415858