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INTRODUCTION: Low back pain is one of the common conditions of loco motor system disorder, affects people during their productive life. About 40% cases of low back pain are of radicular in origin and considered under the umbrella of sciatic syndrome. It is a pain dominant disease and reduces human activity considerably in terms of personal as well as social and professional life. The condition resembles disease Gridhrasi mentioned in Ayurveda under the umbrella of Vatavyadhi, and here piercing type of pain which restricts the movement of the affected leg, make his walking pattern-like bird vulture and put him in disgraceful condition. AIM: To assess the effect of Vatari Guggulu on the management of Gridhrasi. MATERIALS AND METHODS: A total of 40 patients of Gridhrasi were registered and Vatari Guggulu 3 tablet (500 mg each) twice a day was administered before meal with lukewarm water for 30 days. RESULTS AND CONCLUSIONS: About 32.35% of the patient improved moderately while mild improvement was observed in 47.09% of the patients. The drug has shown better effect on patients of Vata Kaphaja type of Gridhrasi in comparison of Vataja type of Gridhrasi.
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INTRODUCTION: Vyaghriharitaki Avaleha (VHA), a polyherbal classical Ayurvedic formulation has been used in Kasa (cough), Swasa (asthma), Rajayakshma (tuberculosis) etc., conditions. AIM: To evaluate the clinical efficacy of VHA in the management of chronic bronchitis. MATERIALS AND METHODS: Patients of chronic bronchitis were given 10 g of VHA twice a day with lukewarm water before meals for 12 weeks. Improvement in clinical symptoms of chronic bronchitis as the primary outcome measures and St. George's Respiratory Questionnaire scores as secondary outcome measure was studied. RESULTS: Out of 66 enrolled patients, 61 completed the treatment schedule. The results show that VHA provides statistically significant improvement with P < 0.001 in both primary and secondary outcome measures. CONCLUSION: VHA can be considered as a safe and effective formulation in the management of chronic bronchitis.
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BACKGROUND: Parikartika resembles fissure-in-ano which is very common among all ano-rectal disorders. In Ayurvedic texts, Parikartika is described as a complication of Vamana and Virechana as well as complication of Atisara. Ksharasutra was proved successful in the management of fistula-in-ano, piles, and there is a need to try its efficacy in fissure-in-ano. AIM: To evaluate the role of Ksharasutra suturing (KSS) in fissure bed in chronic fissure-in-ano. MATERIALS AND METHODS: Total 100 patients of chronic fissure-in-ano were selected and randomly divided into two groups (50 in each group). In group-A, patients were undergone by KSS; while in patients of Group-B Lord's anal dilatation followed by KSS was done under spinal anesthesia. The KSS was done once and after slough out of Ksharasutra, the wound was treated for 4 weeks and assessment of the result was done on the basis of gradation adopted. RESULTS: The pain relief on 14(th) day in Group-A was 86% while in Group-B 100% was observed. As on 7(th) day in Group-A, oozing was stopped in 68% patients, while in Group-B, oozing was stopped in 82% patients. On 21(st) day, Group-B showed more healing (85%) as compared to Group-A (69%). In this study 68% of patients were cured. CONCLUSION: In Group-B (KSS with Lord's anal dilatation) patients were cured early as compared to patients of Group-A (KSS alone).
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Internal oleation (Snehana) is a major preparatory procedures performed before Bio-Purification (Shodhana). Oleation leads and decides the total outcome of the Bio-purification therapy; hence, standard guidelines are needed for performing the internal oleation in an effective manner and also for avoiding the inadequate and excess oleation. It is obligatory to start and increase the dose of lipids (Sneha) in appropriate and judicious way considering the bio-fire (Agni) and nature of bowel habit (Koshtha) of the subject. The outcome of Bio-Purification depends upon proper mobilization of Dosha from the periphery (Shakha) to gastrointestinal tract (Koshtha); which is achieved with the help of oleation therapy (Snehana Karma) and sudation therapy (Svedana Karma). This clinical study was carried out on 29 subjects to standardize the dose and duration of internal oleation and to develop the oleation grade for the assessment of internal oleation therapy. The selected subjects were randomly divided into two groups, in which group A was given fixed increase dose of ghee and in group B non-fixed increase dose was given. Results of this study show that the total percentage of oleation was 33.57% in group A and it was 45.28% in group B. Subjects of Group B (non-fixed dose schedule) have shown better oleation in all the aspects, i.e. duration, oleation grade, and purification grade.
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Irritable bowel syndrome (IBS) is one of the most common conditions encountered in clinical practice but one of the least well understood. Symptoms of this disorder are chronic, sometimes severe and often respond poorly to treatment, resulting in reduced quality of life. There is no specific test for IBS, although diagnostic tests may be performed to rule out other problems. In present clinical trial 51 patients of IBS were registered out of which 46 patients completed the treatment. Bilvadileha was administered for the duration of 12 weeks. The therapy showed statistically significant improvement in all the clinical features of IBS as well as in the IBS severity score.
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Infertility is a problem of global proportions, affecting on an average 8-12% of couples worldwide. Low sperm count (Oligozoospermia) is one of the main causes of male infertility and it is correlated with Kshina Shukra. The fruits of Gokshura (Tribulus terrestris. Linn) are considered to act as a diuretic and aphrodisiac; they used for urolithiasis, sexual dysfunctions, and infertility. Hence, it was planned to study the effect of Gokshura in the management of Kshina Shukra (Oligozoospermia), and to evade the preconception, a double-blind, randomized, placebo-controlled study was designed. In this study, eligible subjects between the age of 21 and 50 years, with a complaint of Kshina Shukra (Oligozoospermia), were randomized to receive either Gokshura granules or placebo granules for 60 days. The primary outcome measures were percentage changes in the Pratyatmaka Lakshanas (cardinal symptoms) of Kshina Shukra, Agni bala, Deha bala, Satva bala, the semenogram, and in the Quality of the Sexual Health Questionnaire. The placebo granules showed 70.95% improvement, whereas, the Gokshura granules showed 78.11% improvement in Rogi bala (Agni bala, Deha bala, Satva bala, and the Quality of Sexual Health) and Rogabala (Semen Analysis and Pratyatmaka Lakshanas). The Gokshura granules have shown superior results in the management of Kshina Shukra, as compared to the placebo granules.
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Population in an industrialized world is afflicted by urinary stone disease. Kidney stones are common in all kinds of urolithiasis. One distinguished formulation mentioned by Sushruta for management of Ashmari (urolithiasis) is Pashanabhedadi Ghrita (PBG), which is in clinical practice since centuries. Validation of drug is the requirement of time through the experimental study. In this study, trial of PBG has been made against ammonium oxalate rich diet and gentamicin injection induced renal calculi in albino rats. The calculi were induced by gentamicin injection and ammonium oxalate rich diet. Test drug was administered concomitantly in the dose of 900 mg/kg for 15 consecutive days. Rats were sacrificed on the 16(th) day. Parameters like kidney weight, serum biochemical, kidney tissue and histopathology of kidney were studied. Concomitant treatment of PBG attenuates blood biochemical parameters non-significantly, where as it significantly attenuated lipid peroxidation and enhanced glutathione and glutathione peroxidase activities. It also decreased crystal deposition markedly into the renal tubules in number as well as size and prevented damage to the renal tubules. The findings showed that PBG is having significant anti-urolithiatic activities against ammonium oxalate rich diet plus gentamicine injection induced urolithiasis in rats.
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Aging has become one of the distinctive demographic phenomena in the 21(st) century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs as a part of the normal aging process. It can be correlated to "Jarajanya Smrtibhramsha" according to Ayurveda. The present study deals with the efficacy of Guduchyadi Medhya Rasayana on Senile Memory Impairment. A total of 138 patients aged in between 55-75 years were registered and randomly divided into two groups as the trial and control groups. The drugs were administered for 3. The trial drug showed memory enhancement, anti-stress, anti-depressant and anxiolytic properties. The trial group showed better results in the management compared to the control group.
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Diabetic population is more than 245 million worldwide and expected to be b380 million by 2025. One of the main causes of increasing rate of diabetes is stress and tension in day-to-day life, disturbing the homeostasis of positive and negative emotions to initiate pathophysiology of stress-induced diabetes. In the present study, in Group A of 34 patients, a herbo-mineral compound containing Shuddha Shilajatu, Shuddha Guggulu, Vijayasara Ghana, Saptarangi Ghana, and Triphala Ghana was administered in the dose of 3 gm/day in three divided doses with luke-warm water before meal for the duration of 8 weeks, which significantly relieved symptoms (60.52%) like Prabhuta Mutrata (54.55%), Avila Mutrata (66.67%), Daurbalya (61.36%), Shrama (59.32%), etc. with fasting blood sugar (4.05%) and postprandial blood sugar (9.95%). In another series of 34 patients (Group B), where psychological health promoting drug Shankhapushpi was administered in the dose of 1.5 gm/day in three divided doses for 8 weeks along with herbo-mineral compound. The percentage relief was found to be more better on symptoms (71.13%) like Prabhuta Mutrata (76.92%), Avila Mutrata (83.33%), Daurbalya (75%), Shrama (70.37%), fasting blood sugar (18.04%) and postprandial blood sugar (27.75%). Group B showed better results on psychological parameters like disturbed Manasabhava (29.16%) and Brief Psychiatry Rating Scale (38.28%). The high significance of χ(2) (15.50) on overall effect of therapy indicated better results in group B.
