Uncertain Malmquist productivity index: An application to evaluate healthcare systems during COVID-19 pandemic.

Evaluation of healthcare systems, as a key organization providing different health services, is essential. This issue becomes more crucial when occurring crises such as a pandemic. They need to keep track of their success in the face of the crisis to assess the effects of policy changes and their capability to respond to new challenges. The Malmquist Productivity Index (MPI) is measured to analyze the causes of productivity change between two periods of time. The estimation of the traditional MPI requires reliable and detailed information on the inputs and outputs of decision-making units. However, there are a lot of situations where input and/or output may be imprecise. It is not manageable to reliably measure certain measurement indices, such as quality of treatment or system flexibility. For such cases, experts are invited to model their opinion. Uncertainty theory is a mathematical branch rationally dealing with belief degrees. The primary objective of this study is to apply MPI concept in the nonparametric approach of data envelopment analysis to calculate the efficiency of systems over different periods of time under uncertain conditions. Accordingly, we consider the MPI when inputs and outputs are belief degrees of experts. Furthermore, the sensitivity of the model is analyzed to determine the reliability of the results to the variation of variables. Finally, as an illustrative example, we explore longitudinal efficiency of healthcare systems during COVID-19 pandemic. According to the results of our model, the majority of the countries have improved in the second period which can be the result of efforts to improve pandemic preparedness. The decomposition of MPI into efficiency changes and technical changes indicates that the rise in productivity is entirely related to the progressive change of the production frontier related to policymaking. This application attempts to demonstrate how crucial it is to take uncertainties into account when comparing the performance of different systems over periods of time. The developed model enables us to consider the uncertainty existing in COVID-19 pandemic. The proposed model can handle more accurately the uncertainty during the pandemic. Thus, the result could be more reliable, which can benefit decision-makers in regard to performance improvement.

On BCG Vaccine Protection from COVID-19: A Review.

Bacille Calmette-Guérin (BCG) vaccine has been globally used to protect infants against tuberculosis (TB) for about a century. This vaccine has been shown to provide some degree of non-specific protection from other respiratory tract infections. This advantage has encouraged researchers to investigate the potential protection of this vaccine from the coronavirus disease 2019 from different perspectives in the ongoing pandemic. In this study, we have comprehensively reviewed the latest articles on potential vaccine effectiveness of BCG on COVID-19 and summarized the possible impacts of the BCG against SARS-COV-2 in detail.

Gonorrhea and syphilis co-infection and related risk factors in HIV patients from Shiraz, South of Iran.

BACKGROUND: Neisseria gonorrhea and Treponema pallidum as an obligate human pathogen are two common causes of sexually transmitted diseases (STDs). The present study aimed to determine the prevalence of N. gonorrhoeae and T. pallidum among human immunodeficiency virus (HIV) patients in the southwest Iran. METHODS: This retrospective study was performed from 2004 to 2013, on HIV patients who were tested for detection of gonorrhea and syphilis infection at Shiraz HIV/AIDS Research Center. ELISA technique was used for preliminary detection of HIV and confirmed by a Western Blotting test. Gonorrhea was routinely diagnosed using direct Gram-staining and culturing on selective agar. Syphilis was routinely diagnosed by RPR test. RESULTS: Of the 806 HIV patients, 39 (2.6%) cases had co-infection with gonorrhea. Compared with mono-HIV infected patients, gonorrhea was significantly more likely among the males (69.4% vs. 92.3%, P=0.002). History of addiction and prison seems to be a significant risk factor for gonorrhea infection (P<0.05). Also, the mean of CD4+lymphocyte was higher among gonorrhea infected patients (368±238 vs. 415±328). Logistic regression analysis showed that sexual contact increased risk of gonococcal infection about 4 fold (OR: 4, CI: 1.7-9.39, P=0.001). None of the HIV patients had syphilis co-infection. CONCLUSIONS: As a preliminary survey, our findings provided unique information on the prevalence of gonorrhea and syphilis co-infections among HIV patients. Moreover, we introduced the main risk factors associated with gonorrhea co-infection in HIV patients in our region including gender, history of addiction and prison, CD4+lymphocyte count, and transmission routes for effective management of STDs.

Acute and chronic tramadol administration impair spatial memory in rat.

Tramadol hydrochloride, a synthetic opioid, acts via a multiple mechanism of action. Tramadol can potentially change the behavioral phenomena. The present study evaluates the effect of tramadol after single or multiple dose/s on the spatial memory of rat using object recognition task (ORT). Tramadol, 20 mg/kg, was injected intraperitoneally (i.p) as a single dose or once a day for 21 successive days considered as acute or chronic treatment respectively. After treatment, animals underwent two trials in the ORT. In the first trial (T1), animals encountered with two identical objects for exploration in a five-minute period. After 1 h, in the T2 trial, the animals were exposed to a familiar and a nonfamiliar object. The exploration times and frequency of the exploration for any objects were recorded. The results showed that tramadol decreased the exploration times for the nonfamiliar object in the T2 trial when administered either as a single dose (P<0.001) or as the multiple dose (P<0.05) compared to the respective control groups. Both acute and chronic tramadol administration eliminated the different frequency of exploration between the familiar and nonfamiliar objects. Our findings revealed that tramadol impaired memory when administered acutely or chronically. Single dose administration of tramadol showed more destructive effect than multiple doses of tramadol on the memory. The observed data can be explained by the inhibitory effects of tramadol on the wide range of neurotransmitters and receptors including muscarinic, N-methyl D-aspartate, AMPA as well as some second messenger like cAMP and cGMP or its stimulatory effect on the opioid, gama amino butyric acid, dopamine or serotonin in the brain.

A new approach for aromaticity criterion based on electrostatic field gradient.

In this research, electric field gradient (EFG), which is the first derivative of electric field, is applied for evaluation of aromaticity of 89 cyclic organic compounds. In our calculations, DFT procedure (b3lyp) with basis set 6-311++G has been employed, and the obtained electronic structures and frequency test has been done for optimized geometries. The aromaticity evaluated for these compounds by EFG procedure is successfully compared with other well-known indices in literature, especially with nuclear independent chemical shift (NICS). These comparisons show that EFG method of assessment of aromaticity can be used as a rather valid procedure for this purpose. Flexibility and simplicity of EFG make this method a rather easy procedure for assessment of aromaticity. Since EFG method of aromaticity evaluation does not need specific programming and it can be done by known software such as Gaussian, therefore, the availability for everyone to calculate desired aromaticity by this method is one of attractive feature of it similar to NICS.