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[Neurodegenerative alterations induced by MPTP neurotoxin in senescence accelerated mice essay].

Fedorova, T N; Stvolinskii, S L; Bagyeva, G H; Ivanova-Smolenskaia, I A; Illarioshkin, S N.

Usp Fiziol Nauk ; 36(2): 94-101, 2005.

Article in Russian | MEDLINE | ID: mdl-15909667

ABSTRACT

Behavioral modifications and alterations in biochemical pathways induced by neurotoxin MPTP in Senescence Accelerated Mice (SAM) brains are discussed. MPTP injections lead to specific injuries of dophaminergic neurons and to reinforcement of oxidative stress conditions. The ability of neuropeptide carnosine to protect animals from oxidative injuries induced by MPTP injections is also described.

Subject(s)

Aging , Brain/metabolism , Neurodegenerative Diseases/metabolism , 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine , Animals , Brain/drug effects , Carnosine/metabolism , Cytoprotection , Disease Models, Animal , Dopamine Agents , Longevity , Mice , Neurodegenerative Diseases/chemically induced , Neurons/drug effects , Neurons/metabolism , Oxidative Stress/drug effects

ABSTRACT

Subject(s)

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