The influence of the Ebola outbreak on presumptive and active tuberculosis in Bombali District, Sierra Leone.

Setting: Bombali District, rural Sierra Leone. Objective: To compare the number of patients with presumptive tuberculosis (TB), the number of patients registered with TB (including testing for the human immunodeficiency virus [HIV] and initiation on antiretroviral therapy [ART]) and treatment outcomes during the pre-Ebola, Ebola and post-Ebola disease outbreak periods between 2013 and 2016. Design: This was a cross-sectional study and retrospective cohort analysis of treatment outcomes. Results: The mean monthly number of patients with presumptive TB before, during and post-Ebola was respectively 169, 145 and 210. The mean monthly number of registered TB cases was respectively 57, 57 and 96. Smear-positive TB was the most frequent type of TB, at 75%, 66% and 77%. The proportion of TB patients tested for HIV was 82% pre-Ebola, 74% Ebola and 99% post-Ebola. The proportion of HIV-positive patients with TB initiated on ART was respectively 46%, 85% and 100%. Treatment success among TB patients was 71% in the pre-Ebola period and 89% in the Ebola period (P < 0.001). Conclusion: During the Ebola outbreak, there were decreases in the number of presumptive TB patients and in the proportions of patients diagnosed with smear-positive TB and tested for HIV. The initiation of ART in HIV-infected TB patients and treatment outcomes remained acceptable. Pre-emptive actions are needed to maintain adequate control activities in future outbreaks.

Contexte : District de Bombali, Sierra Leone rurale.Objectif : Comparer le nombre de patients présumés tuberculeux (TB), le nombre enregistrés comme TB (incluant le test du virus de l'immunodéficience humaine [VIH] et la mise en route du traitement antirétroviral [TAR]) et les résultats du traitement pendant les périodes avant, pendant et après Ebola, entre 2013 et 2016.Schéma : Une étude transversale et analyse rétrospective de cohorte des résultats du traitement.Résultats : Le nombre moyen mensuel de patients présumés TB a été 169 avant Ebola, 145 pendant Ebola et 210 après Ebola. Le nombre mensuel moyen de cas de TB enregistrés a été 57 avant Ebola, 57 pendant Ebola et 96 après Ebola. La TB à frottis positif a été le type le plus fréquent, avec 75% avant Ebola, 66% pendant Ebola et 77% après Ebola. Les proportions de patients tuberculeux testés pour le VIH ont été 82% avant Ebola, 74% pendant Ebola et 99% après Ebola et pour les patients tuberculeux VIH positifs mis sous TAR, ces proportions ont été 46% avant Ebola, 85% pendant Ebola et 100% après Ebola. Le taux de succès du traitement des patients tuberculeux a été de 71% pendant les périodes avant Ebola et de 89% pendant Ebola (P < 0,001).Conclusion : Pendant la période de l'Ebola, il y a eu une diminution du nombre de patients présumés tuberculeux et dans les proportions de patients ayant eu un diagnostic de TB à frottis positif et un test VIH. La mise en route du TAR chez les patients infectés par le VIH et les résultats du traitement sont restés acceptables. Des actions préventives sont requises afin de maintenir des activités de lutte suffisantes lors de futures flambée épidémiques.

Marco de referencia: El distrito rural de Bombali en Sierra Leona.Objetivo: Comparar el número de pacientes con presunción clínica de tuberculosis (TB), el número de casos registrados de TB (con inclusión de las pruebas diagnósticas del virus de la inmunodeficiencia humana [VIH] y el inicio del tratamiento antirretrovírico [TAR]) y los desenlaces terapéuticos durante el período anterior a la epidemia del Ébola, durante la misma y después de ella del 2013 al 2016.Método: Un estudio transversal con un análisis retrospectivo de cohortes de los desenlaces terapéuticos.Resultados: El promedio mensual de pacientes con presunción clínica de TB fue como sigue: 169 antes de la epidemia del Ébola, 145 durante la epidemia y 210 después de la misma. El promedio mensual de casos registrados de TB fue 57 antes de la epidemia, 57 durante el brote y 96 después de la misma. La TB con baciloscopia positiva fue el tipo de enfermedad más frecuente y su proporción fue 75% antes de la epidemia del Ébola, 66% durante la misma y 77% después de ella. La proporción de pacientes TB que contaban con pruebas diagnósticas del VIH fue como sigue: 82% antes de la epidemia, 74% durante la misma y 99% después de ella y la proporción de pacientes con diagnóstico de TB y positivos frente al VIH que iniciaron el TAR fue 46% antes de la epidemia, 85% durante la misma y 100% después de ella. El éxito del tratamiento antituberculoso fue de 71% en el período anterior al brote de enfermedad del Ébola y de 89% en el período posterior al mismo (P < 0,001).Conclusión: Durante el período de la epidemia de enfermedad del Ébola se observó una disminución del número de casos con presunción clínica de TB, de la proporción de diagnósticos de TB con baciloscopia positiva y de la proporción de pacientes con pruebas diagnósticas del VIH. La iniciación del TAR en los pacientes coinfectados por el VIH y TB y los desenlaces terapéuticos conservaron proporciones aceptables. Se precisan intervenciones anticipativas, con el fin de mantener actividades de control adecuadas durante los brotes epidémicos en el futuro.

[Knowledge and practices of hypertension in nursing staff of the Hospital Gabriel Touré and Point G]. / Pratiques et connaissances sur l'hypertension arterielle du personnel soignant des CHU Gabriel Toure et Point G.

OBJECTIVE: This work aimed to study the quality of diagnosis and management of high blood pressure (HBP) by the practitioners of the Gabriel TOURÉ and point G teaching hospitals of Bamako. MATERIALS AND METHODS: It was a descriptive and analytical, cross-sectional study during the study period from 1st March 2009 to 28 February 2010. It included all physicians and paramedics of the teaching hospital of the Point G and Gabriel TOURÉ in Bamako. RESULTS: A total of 283 practitioners (physicians and the paramedics) from both teaching hospitals have accepted our questionnaire, including 133 doctors and 185 paramedics. CHU Gabriel TOURÉ accounted for 55.1%, the majority came from the department of cardiology with 18.4%. Doctors accounted for the largest square with 47.0%. The majority of our practitioners (59%) say it takes at least one session during three medical consultations to diagnose the HBP. Only 29,60% define the HBP from 140/90 mm Hg. With a blood pressure goal of 58, 30% and 57.20% of practitioners claimed to retain 140/90 mm Hg, respectively for the diabetic and the renal-insufficient patients. A considerable number of our practitioners (27.9%) still used in pregnant women the triplet diuretic/IEC/diet without salt. The information of patients on some important aspects of the pathology prior to any therapeutic strategy had been conducted in 63.6. CONCLUSION: The high blood pressure must be a major concern for medical and paramedical staff today.

OBJECTIF: Ce travail visait à étudier la qualité du diagnostic et de la prise en charge de l'hypertension artérielle par les praticiens du CHU Gabriel TOURE et de point G de Bamako. MATÉRIELS ET MÉTHODES: Il s'agissait d'une étude transversale descriptive et analytique, pendant la période d'étude du 1er mars 2009 au 28 Février 2010. Elle a concerné l'ensemble des médecins et des paramédicaux des centres hospitalo ­ universitaires du Point G et Gabriel TOURE de Bamako. RÉSULTATS: Au total 283 praticiens (médecins et des paramédicaux) des deux centres hospitalo - universitaires ont accepté notre questionnaire, dont 133 médecins et 185 paramédicaux. Le CHU Gabriel TOURE représentait 55,1%, la majorité provenait du service de cardiologie avec 18,4%. Les médecins ont constitué la plus grande proportion avec 47,0%. La majorité de nos praticiens (59%) affirmaient qu'il faut au moins une séance de prise tensionnelle pendant trois consultations médicales pour diagnostiquer l'HTA. Seulement 29,60% définissent l'HTA à partir de 140/90 mm Hg. Comme objectif tensionnel 58, 30% et 57,20% des praticiens affirmaient retenir 140/90 mm Hg respectivement chez le diabétique et l'insuffisant rénal. Un nombre considérable de nos praticiens (27,9 %) utilisait encore chez la femme enceinte le triplet Diurétique/IEC/Régime sans sel. L'information des patients sur certains aspects importants de la pathologie avant toute stratégie thérapeutique avait été effectuée dans 63,6. CONCLUSION: L'hypertension artérielle doit être une préoccupation majeure pour tout personnel médical et paramédical de nos jours.

[Simultaneous bilateral percutaneous nephrolithotomy: Series of 60 cases]. / Néphrolithotomie percutanée bilatérale en un temps: série de 60 cas.

OBJECTIVE: Retrospective evaluation of the efficacy and morbidity of simultaneous bilateral percutaneous nephrolithotomy (SB-PCNL). METHODS: From January 1993 to July 2009, 60 patients have undergone SB-PCNL over a series of 1709 PCNL. Thirty men and 30 women, mean age 45 years old (13-78), were treated for bilateral renal stones (120 kidneys) of 1177 mm(2) (268-4972 mm(2)); 25 were complete staghorn stones. RESULTS: Operating time for the first side of PCNL was 80 min (30-270) and 45 min (10-90) for the opposite side. Overall OR occupation was 188 min (90-360). Forty-five patients were stone free after one session; 15 patients (25%) have a complementary treatment to be stone free: five PCNL (one bilateral); eight ESWL (four with JJ stent) and two flexible ureteroscopy. No blood transfusion was required. Renal function was unchanged at 1 month. Clavien grade for complications were as follows: two grade IIIb, one grade IVa and one grade IVb. Hospitalization stay was 4±4.9 days (2-35) taking account of two major sepsis (one pulmonary and one septicemia). CONCLUSION: SB-PCNL was well tolerated with comparable morbidity and efficacy to PCNL performed on each side in two separate sessions. Nevertheless, SB-PCNL has to be performed for selected patients in expert centers.

[Clinical aspects and management of the torsion of the spermatic cord: study of 27 cases]. / Aspects cliniques et thérapeutiques de la torsion du cordon spermatique : étude de 27 cas.

OBJECTIVE: To analyze in a retrospective way the clinical and therapeutical aspects of the testicular torsion in our service. PATIENTS AND METHODS: It is a retrospective survey of 15 years, from June 1st, 1993 to May 31 2008 to the urology - Andrology service of Conakry. We have 27 files of patients with torsion of the spermatic cord confirmed to the intervention. A percentage of 70.30% patients were less than 25 years old. RESULTS: The scrotal pain was the most frequent functional sign (96.3%). Only 11 patients (40.7%) have been received before the sixth hour. The swelling of the scrotum, ascended testis and the sign of Prehn were the dominant physical signs. All patients have been operated. The number of spire towers varied from 1 to 3. Twenty-two testes (81.5%) have been judged viable and fixed. With a median follow-up of 60 months, the testes volume of these patients was stable in 20 cases (90.9%). The postoperative course was simple in 96.3% of cases. Twenty-three patients (85.2%) were released within a week. CONCLUSION: Torsion of the spermatic cord remained a dangerous affection because putting in game the vital prognosis of the testis. The only justifiable attitude is the urgent surgical operation.

[The profile urological emergencies at the Conakry University Teaching Hospital, Guinea]. / Le profil des urgences urologiques au CHU de Conakry, Guinée.

OBJECTIVE: To stick out the profile urological emergencies at the Conakry University Teaching Hospital, Guinea. PATIENTS AND METHODS: This retrospective study, carried out over a period of 3 years (January 2005-December 2007), included 757 urological emergencies admitted to the urology department of the university hospital of Conakry, Guinea. RESULTS: The mean age of patients was 56 years. These patients had an age equal to or higher than 60 years in 58% of the cases. The sex ratio (M/F) was 16.6. According to the social profession, the farmer (40,6%) and workers (21%) were the dominant patients. The most frequent illness was vesical urinary retention (73.9%), hematuria (9.6%) and genito-urinary system trauma (7%). The most performed procedures were the installation of a urethral catheter (55.25%) and the installation of a suprapubic catheter (24.14%). CONCLUSION: The most frequent urological emergency in our country was vesical urinary retention, the hematuria and genito-urinary system trauma are not rare there.

[Etiological orientation from the analysis morphological and constitutional of urinary stones in Conakry]. / Orientation etiologique a partir de l'analyse morphologique et constitutionnelle des lithiases urinaires a Conakry.

INTRODUCTION: The epidemiological profile of urinary stones varies from region of the world to another according to food habit and certain enviromental factors. The aim of our study was to establish an etiological approach of the urinary lithiasis collected in Conakry by morphological and constitutional analysis. MATERIALS AND METHODS: It was a prospective study from january 1 rst 2003 to january 1 rst 2004 concerning all the stones collected. They were analysed by binocular magnifying glass and infra red spectrophotometry of Fourier. RESULTS: During the period, 18 patients were observed (14 male, 4 femele) of 27.4 +/- 4 years old (from 2 to 69) living mainly in urban environment. From these patients 28 stones were collected; 12 spontaneously and 16 surgicaly. Their composition were whewellite (36%), struvite (29%), carbapatite (14%), urates (14%) and weddellite (7%). In Conakry stones come mainly from hyperoxaluria and urinary tract infection; hypercalciuria is uncomon. CONCLUSION: The urinary calculations examined among patients show in the adult a prevalence of elements in favour of a hyperoxalurie and a notable context of urinary infections in particular in the child; the pure hypercalciurie remains negligible in Conakry, we plan to lead a thorough work to the national scales.

Les ruptures traumatiques de l'uretre posterieur : analyse de 87 cas au CHU de Conakry

Objectif : Rapporter notre experience dans la prise en charge des ruptures traumatiques de l'uretre posterieur. Patients et methodes : Quatre-vingt-sept patients presentant une rupture traumatique de l'uretre posterieur ont ete traites dans le service d'Urologie-Andrologie du CHU de Conakry de janvier 1988 a decembre 2004. Le contexte traumatique a ete un accident de la voie publique dans 68 (78;2) cas et un accident de travail dans 19 (21;8) cas. Seuls 32 (36;8) des patients ont ete recus dans les 72 heures qui ont suivi le traumatisme; les autres ont ete recus au stade de stenose uretrale constituee. Une fracture du bassin a ete notee chez 56 (64;4) patients. La symptomatologie clinique etait dominee par la retention d'urine dans 62 (71;3); l'uretrorragie dans 59 (67;8) et l'hematome perineal dans 23 (26;4) cas. Resultats : Le traitement a consiste en un realignement sur sonde uretrale en urgence; une reparation uretrale en urgence differee entre le 8e et le 10e jour et une uretroplastie tardive selon qu'il s'agissait d'une rupture recente ou ancienne de l'uretre. Les resultats therapeutiques ont ete bons dans 32 (36;8) et moyens dans 39 (44;8) cas. Une dysfonction erectile a ete notee chez 19 (21;8) patientsConclusion : Le traitement des ruptures de l'uretre posterieur demeure controverse; cependant pour nous; l'uretrorraphie termino-terminale en urgence differee reste la methode therapeutique de choix dans notre contexte devant l'impossibilite de pouvoir realiser un realignement endoscopique et en l'absence de lesions associees severes. Devant des lesions associees graves la refection uretrale passe au second plan cedant la priorite aux lesions engageant le pronostic vital

[Aspects of genital tuberculosis in women]. / Aspects de la tuberculose génitale de la femme.

Thirteen cases of genital tuberculosis are reported to make emphasis onto the difficulties of diagnosis, management and prognosis of the disease. The average age of the patients is 31 years. Most of them were under 30. The circumstances of diagnosis were variable. The diagnosis was essentially made thanks to histology. The evolution was favorable under antibiotics. But clinical sequels as amenorrhea and infertility are frequent.