ABSTRACT
BACKGROUND: Hard corns are firm, small, dome-shaped papules with translucent central cores, which occur on the palmoplantar region of toes and hands due to repeated trauma. Medical management of hard corns is difficult and sometimes requires surgical excision. Punch incision is a technique which is performed using a circular blade or trephine attached to a pencil-like handle. AIM: We hypothesized that it might serve as an alternative method to surgical excision in the treatment of recalcitrant corns and performed the technique to treat 17 corns in 15 patients. The present study aimed to review these 15 patients retrospectively and evaluate the effectiveness of punch incision. METHOD: A total of 15 patients with recalcitrant corns were treated using punch incision between April 2011 and December 2012 and were evaluated by photographs and patient satisfaction questionnaires. RESULTS: Out of the 17 corns, 3 corns persisted after punch incision and the patients were referred to the orthopedic clinic for further treatment; 2 of the 17 corns partially responded and required additional topical treatment; and 12 of the 17 corns responded completely to punch incision. CONCLUSION: Punch incision is a simple and effective technique for the treatment of small corns on the palms and soles.
Subject(s)
Callosities/surgery , Adult , Callosities/drug therapy , Female , Humans , Male , Middle Aged , Patient Satisfaction , Photography , Recurrence , Retreatment , Retrospective Studies , Treatment Outcome , Young AdultABSTRACT
AIM: To investigate the association of the HLA-C allele with psoriasis. Methods Twenty five type I psoriasis patients with 25 healthy controls participated in this study. PCR-SSP was preferred for HLA-C typing. The patients were questioned for age at onset and family history and examined for severity and area of involvement of the disease and presence of articular, nail and scalp involvement. PCRSSP method was preferred for HLA-C typing. Statistical analyses were made using the Chi-square test. Relative risk was assessed to determine the association between disease and HLA antigen. RESULTS: The increase prevalence of HLA-Cw6 antigen among type I psoriasis vulgaris patients (p=0.0047) compared with healthy controls was noticed, but not in the prevalence of other HLA-C alleles. Among psoriasis patients, 14 (56%) had a positive family history. Among all patients, eight (32%) had articular symptoms, 19 (76%) had nail involvement, and all subjects had scalp involvement. Onset of disease was 6.7 years earlier in patients with positive family history compared with negative family history. No significant association was found between HLA-C alleles and family history, clinical findings or severity of the disease. CONCLUSION: Our findings are consistent with previous studies that have shown association between HLA-Cw6 antigen and early onset of the disease. Clarifying the role of HLA-Cw6 antigen in the etiopathogenesis provides important advances in gene therapy for psoriasis.
