Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Biol Chem ; 287(21): 17331-17342, 2012 May 18.
Article in English | MEDLINE | ID: mdl-22433862

ABSTRACT

Maurocalcine is the first demonstrated example of an animal toxin peptide with efficient cell penetration properties. Although it is a highly competitive cell-penetrating peptide (CPP), its relatively large size of 33 amino acids and the presence of three internal disulfide bridges may hamper its development for in vitro and in vivo applications. Here, we demonstrate that several efficient CPPs can be derived from maurocalcine by replacing Cys residues by isosteric 2-aminobutyric acid residues and sequence truncation down to peptides of up to 9 residues in length. A surprising finding is that all of the truncated maurocalcine analogues possessed cell penetration properties, indicating that the maurocalcine is a highly specialized CPP. Careful examination of the cell penetration properties of the truncated analogues indicates that several maurocalcine-derived peptides should be of great interest for cell delivery applications where peptide size matters.


Subject(s)
Cell-Penetrating Peptides/pharmacology , Scorpion Venoms/pharmacology , Animals , CHO Cells , Cell-Penetrating Peptides/chemical synthesis , Cell-Penetrating Peptides/chemistry , Cricetinae , Cricetulus , Scorpion Venoms/chemical synthesis , Scorpion Venoms/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...