ABSTRACT
Epithelial mucinosis (follicular mucinosis) is a reactive histological pattern characterized by the accumulation of mucin in the infundibular, follicular, and sebaceous epithelium, that may occur in multiple skin conditions and cannot be considered a specific disease. Alopecia mucinosa is a clinicopathological entity with distinctive skin lesions, mucin deposits in the hair follicles and periadnexal lymphoid infiltrates. Three types of mucinous alopecia have been described: idiopathic, persistent or benign chronic, and associated to lymphoma. For some authors, these types of mucinous alopecia are not independent diseases, but rather represent variants of mycosis fungoides with epithelial mucinosis.
Subject(s)
Mucinosis, Follicular , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Child, Preschool , Follow-Up Studies , Humans , Immunohistochemistry , Male , Mucinosis, Follicular/diagnosis , Mucinosis, Follicular/pathology , Ointments , Skin/pathology , Time Factors , Treatment OutcomeABSTRACT
La mucinosis epitelial (mucinosis folicular) es un patrón histológico reactivo caracterizado por la acumulación de mucina en el epitelio infundibular, folicular o sebáceo, que puede ocurrir en múltiples procesos cutáneos, y que no puede ser considerada una enfermedad específica. La alopecia mucinosa es una entidad clinicopatológica con lesiones cutáneas distintivas, depósitos de mucina en los folículos pilosos e infiltrados linfoides perianexiales. Se han descrito tres tipos de alopecia mucinosa: idiopática, persistente o crónica benigna y asociada a linfoma. Para algunos autores, estos tipos de alopecia mucinosa no son enfermedades independientes, sino que representan variantes de micosis fungoides con mucinosis epitelial
Epithelial mucinosis (follicular mucinosis) is a reactive histological pattern characterized by the accumulation of mucin in the infundibular, follicular, and sebaceous epithelium, that may occur in multiple skin conditions and cannot be considered a specific disease. Alopecia mucinosa is a clinicopathological entity with distinctive skin lesions, mucin deposits in the hair follicles and periadnexal lymphoid infiltrates. Three types of mucinous alopecia have been described: idiopathic, persistent or benign chronic, and associated to lymphoma. For some authors, these types of mucinous alopecia are not independent diseases, but rather represent variants of mycosis fungoides with epithelial mucinosis
Subject(s)
Male , Child , Humans , Mucinosis, Follicular/diagnosis , Mucinosis, Follicular/therapy , Mucinosis, Follicular/complications , Mycosis Fungoides/diagnosis , Mycosis Fungoides/therapy , Immunohistochemistry/methods , Polymerase Chain Reaction/methods , Immunohistochemistry/trends , Medical History Taking/methods , Phototherapy/methods , Phototherapy/trends , Phototherapy , Isotretinoin/therapeutic use , Dapsone , Dapsone/therapeutic useABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Erythema/diagnosis , Erythema/therapy , Cachexia/diagnosis , Biopsy , Tomography, Emission-Computed/methods , Carcinoma/diagnosis , Colonoscopy/methods , Immunohistochemistry/methods , Diagnosis, Differential , Combined Modality Therapy , Umbilicus/pathology , Cachexia/complications , Carcinoma/complications , Erythema/complications , Umbilicus/surgery , Umbilicus , Hyperuricemia/complications , Abdominal Neoplasms/diagnosis , Abdominal Neoplasms/therapyABSTRACT
Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination. We present a case of MCC in a male patient with chronic lymphocytic leukemia (CLL). The immunosuppression induced by the leukemia or by the chemotherapy could play a pathogenic role in the association of these diseases. Positron emission tomography (PET) was a useful staging technique in this patient, and made the differential diagnosis of the lymph node involvement from MMC and CLL possible.
Subject(s)
Carcinoma, Merkel Cell/pathology , Leukemia, Lymphocytic, Chronic, B-Cell , Neoplasms, Second Primary/pathology , Skin Neoplasms/pathology , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Merkel Cell/diagnostic imaging , Carcinoma, Merkel Cell/radiotherapy , Carcinoma, Merkel Cell/secondary , Carcinoma, Merkel Cell/surgery , Cyclophosphamide/adverse effects , Cyclophosphamide/therapeutic use , Diagnosis, Differential , Humans , Immunocompromised Host , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell/immunology , Lymph Node Excision , Lymphatic Metastasis/radiotherapy , Male , Middle Aged , Neoplasms, Second Primary/diagnostic imaging , Neoplasms, Second Primary/radiotherapy , Neoplasms, Second Primary/surgery , Positron-Emission Tomography , Prednisone/adverse effects , Prednisone/therapeutic use , Radiotherapy, Adjuvant , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/surgery , Vincristine/adverse effects , Vincristine/therapeutic useABSTRACT
El carcinoma de células de Merkel (CCM) es un tumor neuroendocrino cutáneo infrecuente con un elevado potencial de recurrencias locales, diseminación linfática y diseminación a distancia. Presentamos un caso de CCM en un paciente con leucemia linfática crónica (LLC). La inmunosupresión inducida por la leucemia o por la quimioterapia podría desempeñar un papel patogénico en la asociación de estas enfermedades. La tomografía por emisión de positrones (PET) es una técnica de estadiaje útil en este paciente, y permite el diagnóstico diferencial de la afectación ganglionar por CCM y LLC
Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination. We present a case of MCC in a male patient with chronic lymphocytic leukemia (CLL). The immunosuppression induced by the leukemia or by the chemotherapy could play a pathogenic role in the association of these diseases. Positron emission tomography (PET) was a useful staging technique in this patient, and made the differential diagnosis of the lymph node involvement from MMC and CLL possible
